BDBM50103601 CHEBI:29007::Ceftriaxone
SMILES [H][C@@]1(NC(=O)C(=N/OC)\c2csc(N)n2)C(=O)N2C(C(O)=O)=C(CSc3nc(=O)c(O)nn3C)CS[C@]12[H]
InChI Key InChIKey=VAAUVRVFOQPIGI-SPQHTLEESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 40 hits for monomerid = 50103601
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone substrate by LC-MS/MS methodMore data for this Ligand-Target Pair
TargetExcitatory amino acid transporter 2(Human)
Drexel University College of Medicine
Curated by ChEMBL
Drexel University College of Medicine
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Activation of human EAAT2 overexpressed in MDCK cells assessed as glutamate reuptake incubated for 5 mins by LCMS assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using omeprazole substrate by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.74E+4nMAssay Description:Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide substrate by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol substrate by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of DAAO (unknown origin)More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S(Human)
Chantest
Curated by ChEMBL
Chantest
Curated by ChEMBL
Affinity DataIC50: 1.54E+5nMAssay Description:Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunitsMore data for this Ligand-Target Pair
TargetPenicillin-binding protein 2B(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: >1.44E+4nMAssay Description:Inhibition of Bocillin FL binding to PBP2b in Streptococcus pneumoniae isolate 8819 harboring E333G, I361L, E369D, S412P, N422Y, T426K, Q427L, Q438E,...More data for this Ligand-Target Pair
TargetPenicillin-binding protein 2B(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: >1.44E+4nMAssay Description:Inhibition of Bocillin FL binding to PBP2b in laboratory-derived Streptococcus pneumoniae isolate R6More data for this Ligand-Target Pair
TargetPenicillin-binding protein 2B(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: >1.44E+4nMAssay Description:Inhibition of Streptococcus pneumoniae isolate 8882 Bocillin FL binding to PBP2b 443SSNA mutantMore data for this Ligand-Target Pair
TargetPenicillin-binding protein 2B(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: >1.44E+4nMAssay Description:Inhibition of Bocillin FL binding to PBP2b PBP2b 443SSNA mutant in Streptococcus pneumoniae isolate 8009 harboring E333G, N470K, E476G, T489S, E506D,...More data for this Ligand-Target Pair
TargetPenicillin-binding protein 2B(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: >1.44E+4nMAssay Description:Inhibition of Bocillin FL binding to Streptococcus pneumoniae isolate 8865 PBP2bMore data for this Ligand-Target Pair
TargetPeptidoglycan D,D-transpeptidase MrdA(Escherichia coli)
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Affinity DataIC50: 360nMAssay Description:Inhibition of bocillin FL binding to Escherichia coli MC4100 penicillin-binding protein 2More data for this Ligand-Target Pair
TargetPutative penicillin-binding protein 2B(Staphylococcus aureus)
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Affinity DataIC50: 901nMAssay Description:Inhibition of bocillin FL binding to methicillin-susceptible Staphylococcus aureus ATCC 29213 penicillin-binding protein 1More data for this Ligand-Target Pair
TargetPenicillin-binding protein 2(Staphylococcus aureus)
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of bocillin FL binding to methicillin-susceptible Staphylococcus aureus ATCC 29213 penicillin-binding protein 2More data for this Ligand-Target Pair
TargetPeptidase(Staphylococcus aureus)
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Affinity DataIC50: >9.01E+4nMAssay Description:Inhibition of bocillin FL binding to methicillin-resistant Staphylococcus aureus OC 3726 penicillin-binding protein 2aMore data for this Ligand-Target Pair
TargetPenicillin-binding protein 3(Staphylococcus aureus)
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of bocillin FL binding to methicillin-susceptible Staphylococcus aureus ATCC 29213 penicillin-binding protein 3More data for this Ligand-Target Pair
TargetPenicillin-binding protein 4(Staphylococcus aureus)
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of bocillin FL binding to methicillin-susceptible Staphylococcus aureus ATCC 29213 penicillin-binding protein 4More data for this Ligand-Target Pair
TargetPeptidase(Staphylococcus aureus)
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Affinity DataIC50: >2.30E+5nMAssay Description:Binding affinity to methicillin-resistant, heteroresistant vancomycin-intermediate, beta-lactamase-negative Staphylococcus aureus 873 PBP2a by compet...More data for this Ligand-Target Pair
TargetPeptidase(Staphylococcus aureus)
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Affinity DataIC50: >2.30E+5nMAssay Description:Binding affinity to methicillin-, linezolid-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 2149A PBP2a by competit...More data for this Ligand-Target Pair
TargetPeptidase(Staphylococcus aureus)
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Affinity DataIC50: 3.60E+3nMAssay Description:Binding affinity to methicillin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 1287 PBP2a by competitive binding a...More data for this Ligand-Target Pair
TargetPeptidase(Staphylococcus aureus)
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Affinity DataIC50: 450nMAssay Description:Binding affinity to against methicillin-, daptomycin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 25 PBP2a by co...More data for this Ligand-Target Pair
TargetPenicillin-binding protein 1A(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Hershey Medical Center
Curated by ChEMBL
Hershey Medical Center
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Binding affinity to against penicillin-susceptible Streptococcus pneumoniae 1076 PBP1A by competitive binding assayMore data for this Ligand-Target Pair
TargetPenicillin-binding protein 1A(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Hershey Medical Center
Curated by ChEMBL
Hershey Medical Center
Curated by ChEMBL
Affinity DataIC50: 450nMAssay Description:Binding affinity to penicillin-resistant Streptococcus pneumoniae 24 PBP1A by competitive binding assayMore data for this Ligand-Target Pair
TargetPenicillin-binding protein 2x(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Hershey Medical Center
Curated by ChEMBL
Hershey Medical Center
Curated by ChEMBL
Affinity DataIC50: 7.21E+3nMAssay Description:Binding affinity to penicillin-resistant Streptococcus pneumoniae 3413 PBP2X by competitive binding assayMore data for this Ligand-Target Pair
TargetPenicillin-binding protein 2B(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 2.88E+4nMAssay Description:Binding affinity to penicillin-resistant Streptococcus pneumoniae 3413 PBP2B by competitive binding assayMore data for this Ligand-Target Pair
TargetPenicillin-binding protein 1A(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Hershey Medical Center
Curated by ChEMBL
Hershey Medical Center
Curated by ChEMBL
Affinity DataIC50: 450nMAssay Description:Binding affinity to penicillin-resistant Streptococcus pneumoniae 2527 PBP1A by competitive binding assayMore data for this Ligand-Target Pair
TargetPenicillin-binding protein 2x(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Hershey Medical Center
Curated by ChEMBL
Hershey Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Binding affinity to penicillin-resistant Streptococcus pneumoniae 24 PBP2X by competitive binding assayMore data for this Ligand-Target Pair
TargetPenicillin-binding protein 2x(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Hershey Medical Center
Curated by ChEMBL
Hershey Medical Center
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Binding affinity to penicillin-resistant Streptococcus pneumoniae 2527 PBP2X by competitive binding assayMore data for this Ligand-Target Pair
TargetPenicillin-binding protein 2B(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: >5.77E+4nMAssay Description:Binding affinity to against penicillin-susceptible Streptococcus pneumoniae 1076 PBP2B by competitive binding assayMore data for this Ligand-Target Pair
TargetPeptidase(Staphylococcus aureus)
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Binding affinity to methicillin-, vancomycin-resistant, beta-lactamase-positive Staphylococcus aureus 510 PBP2a by competitive binding assayMore data for this Ligand-Target Pair
TargetPenicillin-binding protein 1A(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Hershey Medical Center
Curated by ChEMBL
Hershey Medical Center
Curated by ChEMBL
Affinity DataIC50: 450nMAssay Description:Binding affinity to penicillin-resistant Streptococcus pneumoniae 3413 PBP1A by competitive binding assayMore data for this Ligand-Target Pair
TargetPenicillin-binding protein 2x(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Hershey Medical Center
Curated by ChEMBL
Hershey Medical Center
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Binding affinity to against penicillin-susceptible Streptococcus pneumoniae 1076 PBP2X by competitive binding assayMore data for this Ligand-Target Pair
TargetPenicillin-binding protein 2B(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 2.88E+4nMAssay Description:Binding affinity to penicillin-resistant Streptococcus pneumoniae 24 PBP2B by competitive binding assayMore data for this Ligand-Target Pair
TargetPenicillin-binding protein 2B(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 7.21E+3nMAssay Description:Binding affinity to penicillin-resistant Streptococcus pneumoniae 2527 PBP2B by competitive binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+6nMAssay Description:TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 8.40E+5nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cellsMore data for this Ligand-Target Pair
Affinity DataKd: 530nMAssay Description:Binding affinity to alpha-synuclein (unknown origin) expressed in Escherichia coli BL21(DE3) by circular dichroism analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin substrate by LC-MS/MS methodMore data for this Ligand-Target Pair