BDBM50105483 (-)-cyclorphan::17-cyclopropylmethyl-(1R,9R)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol::17-cyclopropylmethyl-(9R)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol::17-cyclopropylmethyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2,4,6-trien-4-ol::CHEMBL291468

SMILES Oc1ccc2C[C@@H]3C4CCCC[C@]4(CCN3CC3CC3)c2c1

InChI Key InChIKey=NLBUEDSBXVNAPB-IPNZSQQUSA-N

Data  6 KI  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50105483   

TargetKappa-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105483((-)-cyclorphan | 17-cyclopropylmethyl-(1R,9R)-17-a...)
Affinity DataKi:  0.0340nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105483((-)-cyclorphan | 17-cyclopropylmethyl-(1R,9R)-17-a...)
Affinity DataKi:  0.0340nMAssay Description:Agonistic activity against kappa opioid receptor in Chinese hamster ovary membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105483((-)-cyclorphan | 17-cyclopropylmethyl-(1R,9R)-17-a...)
Affinity DataKi:  0.0620nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105483((-)-cyclorphan | 17-cyclopropylmethyl-(1R,9R)-17-a...)
Affinity DataKi:  0.0620nMAssay Description:Inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 of Chinese hamster ovary membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105483((-)-cyclorphan | 17-cyclopropylmethyl-(1R,9R)-17-a...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of [3H]naltrindole binding to opioid receptor delta 1 of Chinese hamster ovary membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105483((-)-cyclorphan | 17-cyclopropylmethyl-(1R,9R)-17-a...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105483((-)-cyclorphan | 17-cyclopropylmethyl-(1R,9R)-17-a...)
Affinity DataEC50:  0.800nMAssay Description:Activity at human mu opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105483((-)-cyclorphan | 17-cyclopropylmethyl-(1R,9R)-17-a...)
Affinity DataEC50:  0.190nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105483((-)-cyclorphan | 17-cyclopropylmethyl-(1R,9R)-17-a...)
Affinity DataEC50:  0.200nMAssay Description:Agonistic activity against kappa opioid receptor in Chinese hamster ovary membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105483((-)-cyclorphan | 17-cyclopropylmethyl-(1R,9R)-17-a...)
Affinity DataIC50:  1.70nMAssay Description:Activity at human mu opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105483((-)-cyclorphan | 17-cyclopropylmethyl-(1R,9R)-17-a...)
Affinity DataEC50:  0.800nMAssay Description:Agonistic activity against Opioid receptor mu 1 in Chinese hamster ovary membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed