BDBM50105763 CHEMBL420081::D3RKN_10::Ethyl-{4-[5-(4-fluoro-phenyl)-3-(1-methyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-amine

SMILES CCNc1nccc(n1)-c1c(ncn1C1CCN(C)CC1)-c1ccc(F)cc1

InChI Key InChIKey=CXEXTPDLKDYOMC-UHFFFAOYSA-N

Data  1 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50105763   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105763(CHEMBL420081 | D3RKN_10 | Ethyl-{4-[5-(4-fluoro-ph...)
Affinity DataIC50:  9.60nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50105763(CHEMBL420081 | D3RKN_10 | Ethyl-{4-[5-(4-fluoro-ph...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2025More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50105763(CHEMBL420081 | D3RKN_10 | Ethyl-{4-[5-(4-fluoro-ph...)
Affinity DataKd:  4.10E+3nMAssay Description:D3R2022More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50105763(CHEMBL420081 | D3RKN_10 | Ethyl-{4-[5-(4-fluoro-ph...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2021More data for this Ligand-Target Pair
In DepthDetails PubMed