BDBM50106301 CHEMBL3598140
SMILES OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2ccccc12
InChI Key InChIKey=DANLZOIRUUHIIX-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 35 hits for monomerid = 50106301
TargetPeroxisome proliferator-activated receptor gamma(Human)
Eindhoven University of Technology
Curated by ChEMBL
Eindhoven University of Technology
Curated by ChEMBL
Affinity DataKi: 160nMAssay Description:Binding affinity to PPARgamma LBD (unknown origin) assessed as inhibition constant in presence of 10 nM of rosiglitazone by HTRF based competitive bi...More data for this Ligand-Target Pair
3D Structure (crystal)TargetPeroxisome proliferator-activated receptor gamma(Human)
Eindhoven University of Technology
Curated by ChEMBL
Eindhoven University of Technology
Curated by ChEMBL
Affinity DataKi: 210nMAssay Description:Binding affinity to PPARgamma LBD (unknown origin) assessed as inhibition constant by HTRF based competitive binding assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
Eindhoven University of Technology
Curated by ChEMBL
Eindhoven University of Technology
Curated by ChEMBL
Affinity DataKi: 230nMAssay Description:Binding affinity to PPARgamma LBD (unknown origin) assessed as inhibition constant in presence of 1 uM of rosiglitazone by HTRF based competitive bin...More data for this Ligand-Target Pair
Affinity DataIC50: 127nMAssay Description:Allosteric inhibition of yeast GAL4 DNA domain-fused RORgammat LBD (97 to 518 residues) (unknown origin) expressed in HEK293T cells after 20 to 22 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 7.80nMAssay Description:Competitive inverse agonist activity at human N-terminal His6-tagged RORgammat LBD (265 to 518 residues) expressed in Escherichia coli BL21 (DE3) ass...More data for this Ligand-Target Pair
Affinity DataIC50: 9.40nMAssay Description:Competitive inverse agonist activity at human N-terminal His6-tagged RORgammat LBD (265 to 518 residues) expressed in Escherichia coli BL21 (DE3) ass...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Competitive inverse agonist activity at human N-terminal His6-tagged RORgammat LBD (265 to 518 residues) expressed in Escherichia coli BL21 (DE3) ass...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
Eindhoven University of Technology
Curated by ChEMBL
Eindhoven University of Technology
Curated by ChEMBL
Affinity DataIC50: 7.20E+3nMAssay Description:Inverse agonist activity at His6-tagged PPARgamma LBD (unknown origin) assessed as inhibition of rosiglitazone-induced N-terminal biotinylated co-act...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Displacement of Alexa647-labeled MRL-87 from human N-terminal His6-tagged RORgammat LBD (265 to 518 residues) expressed in Escherichia coli BL21 (DE3...More data for this Ligand-Target Pair
Affinity DataIC50: 7.80nMAssay Description:Inverse agonist activity at human N-terminal His6-tagged RORgammat LBD (265 to 518 residues) expressed in Escherichia coli BL21 (DE3) assessed as inh...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Allosteric inverse agonist activity at recombinant human N-terminal His6-tagged RORgammat ligand binding domain (265 to 518 residues) expressed in Es...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Allosteric inverse agonist activity at 2-chloro-5-nitro-N-o-tolylbenzamide-ligated recombinant human N-terminal His6-tagged RORgammat ligand binding ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Allosteric inverse agonist activity at 2-chloro-N-(2,6-dimethylphenyl)-5-nitrobenzamide-ligated recombinant human N-terminal His6-tagged RORgammat li...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Allosteric inverse agonist activity at 2-chloro-5-nitro-N-(2-(trifluoromethyl)phenyl)benzamide-ligated recombinant human N-terminal His6-tagged RORga...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of His6-tagged human RORgammat LBD expressed in Escherichia coli BL21(DE3) cells after 16 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of RORgammat in human PBMC by IL17A assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
Eindhoven University of Technology
Curated by ChEMBL
Eindhoven University of Technology
Curated by ChEMBL
Affinity DataKd: 250nMAssay Description:Binding affinity to PPARgamma LBD (unknown origin) assessed as dissociation constant followed by heating for 3 mins by Bradford assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
Eindhoven University of Technology
Curated by ChEMBL
Eindhoven University of Technology
Curated by ChEMBL
Affinity DataEC50: 170nMAssay Description:Partial agonist activity at PPARgamma LBD (unknown origin) assessed as increase in FITC-labeled PGC-1alpha coactivator peptide recruitment by HTRF as...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
Eindhoven University of Technology
Curated by ChEMBL
Eindhoven University of Technology
Curated by ChEMBL
Affinity DataEC50: 230nMAssay Description:Binding affinity to PPARgamma LBD (unknown origin) using FITC-labeled PGC-1alpha peptide in presence of 10 nM of rosiglitazone by HTRF based competit...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
Eindhoven University of Technology
Curated by ChEMBL
Eindhoven University of Technology
Curated by ChEMBL
Affinity DataEC50: 9.10E+3nMAssay Description:Binding affinity to PPARgamma LBD (unknown origin) using FITC-labeled PGC-1alpha peptide in presence of 1 uM of rosiglitazone by HTRF based competiti...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
Eindhoven University of Technology
Curated by ChEMBL
Eindhoven University of Technology
Curated by ChEMBL
Affinity DataEC50: 1.30E+3nMAssay Description:Partial agonist activity at PPARgamma LBD (unknown origin) assessed as increase in FITC-labeled PGC-1alpha coactivator peptide recruitment in presenc...More data for this Ligand-Target Pair
Affinity DataEC50: 4.70nMAssay Description:Partial agonist activity at RORgammat (unknown origin) assessed as increase in FITC-labeled SRC1B2 peptide recruitment by HTRF assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
Eindhoven University of Technology
Curated by ChEMBL
Eindhoven University of Technology
Curated by ChEMBL
Affinity DataIC50: 6.30E+3nMAssay Description:Inverse agonist activity at His6-tagged PPARgamma LBD (unknown origin) assessed as N-terminal biotinylated PGC1a coactivator peptide recruitment in p...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
Eindhoven University of Technology
Curated by ChEMBL
Eindhoven University of Technology
Curated by ChEMBL
Affinity DataEC50: 340nMAssay Description:Inverse agonist activity at His6-tagged PPARgamma LBD (unknown origin) assessed as N-terminal biotinylated PGC1a coactivator peptide recruitment by T...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Allosteric inverse agonist activity at C-terminal His-tagged RORgammat LBD (265 to 507 residues) (unknown origin) expressed in Escherichia coli BL21(...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Displacement of Alexa flour647-labeled MRL-871 from RORgammat LBD (265 to 507 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cell...More data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:Inverse agonist activity at RORC (unknown origin)More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
Eindhoven University of Technology
Curated by ChEMBL
Eindhoven University of Technology
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inverse agonist activity at human PPARgammaMore data for this Ligand-Target Pair
Affinity DataIC50: 425nMAssay Description:Inhibition of RORgammat (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inverse agonist activity at His6-tagged human RORgammat LBD expressed in Escherichia coli BL21(DE3) assessed as decrease in SRC-1 recruitment using B...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Compound was evaluated for the inhibition of Escherichia coli Thymidylate SynthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Allosteric inhibition of recombinant His6-tagged RORgammat LBD (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition of bio...More data for this Ligand-Target Pair
Affinity DataIC50: 6.10nMAssay Description:Inhibition of human GAL4-fused RORgammat LBD transfected in Escherichia coli BL21(DE3) cell measured after 16 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
Eindhoven University of Technology
Curated by ChEMBL
Eindhoven University of Technology
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Displacement of fluormone PPARgamma green from GST-tagged human PPARgamma-LBD after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair