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BDBM50107778 Biphenyl-2-carboxylic acid (2-benzenesulfonylamino-indan-5-yl)-amide::CHEMBL143535

SMILES: O=C(Nc1ccc2CC(Cc2c1)NS(=O)(=O)c1ccccc1)c1ccccc1-c1ccccc1

InChI Key: InChIKey=PYHWTMOCTYEEAJ-UHFFFAOYSA-N

Data: 2 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50107778   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50107778
PNG
(Biphenyl-2-carboxylic acid (2-benzenesulfonylamino...)
Show SMILES O=C(Nc1ccc2CC(Cc2c1)NS(=O)(=O)c1ccccc1)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C28H24N2O3S/c31-28(27-14-8-7-13-26(27)20-9-3-1-4-10-20)29-23-16-15-21-17-24(19-22(21)18-23)30-34(32,33)25-11-5-2-6-12-25/h1-16,18,24,30H,17,19H2,(H,29,31)
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KEGG

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 710n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against MTP using MTP transfer assay


J Med Chem 44: 4677-87 (2001)


Article DOI: 10.1021/jm010294e
BindingDB Entry DOI: 10.7270/Q23F4NXH
More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107778
PNG
(Biphenyl-2-carboxylic acid (2-benzenesulfonylamino...)
Show SMILES O=C(Nc1ccc2CC(Cc2c1)NS(=O)(=O)c1ccccc1)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C28H24N2O3S/c31-28(27-14-8-7-13-26(27)20-9-3-1-4-10-20)29-23-16-15-21-17-24(19-22(21)18-23)30-34(32,33)25-11-5-2-6-12-25/h1-16,18,24,30H,17,19H2,(H,29,31)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 12n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)


Article DOI: 10.1021/jm010294e
BindingDB Entry DOI: 10.7270/Q23F4NXH
More data for this
Ligand-Target Pair