BDBM50109028 CHEMBL3600447

SMILES CCCc1nc(C[C@H](NC(=O)c2cnc(C)cn2)C(=O)N2CCC[C@H]2C(N)=O)c[nH]1

InChI Key

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50109028   

TargetThyrotropin-releasing hormone receptor(Mus musculus)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50109028(CHEMBL3600447)
Affinity DataIC50: >5.00E+4nMAssay Description:Displacement of [3H]-1-MeHis-TRH from mouse TRH-R2 expressed in HEK293 cells incubated up to 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyrotropin-releasing hormone receptor(Mus musculus)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50109028(CHEMBL3600447)
Affinity DataEC50:  15nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyrotropin-releasing hormone receptor(MOUSE)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50109028(CHEMBL3600447)
Affinity DataEC50:  17nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyrotropin-releasing hormone receptor(MOUSE)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50109028(CHEMBL3600447)
Affinity DataIC50: >5.00E+4nMAssay Description:Displacement of [3H]-1-MeHis-TRH from mouse TRH-R1 expressed in HEK293 cells incubated up to 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed