BDBM50109056 5-{2-[4-(1H-Pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethoxy}-quinoline::CHEMBL442391

SMILES C(CN1CCC(=CC1)c1c[nH]c2ncccc12)Oc1cccc2ncccc12

InChI Key InChIKey=QFIPWGPAGDXIEC-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50109056   

TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109056(5-{2-[4-(1H-Pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydr...)
Affinity DataKi:  6.90nMAssay Description:Affinity of the compound for RB Serotonin transporter was determined in vitro by incubating compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109056(5-{2-[4-(1H-Pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydr...)
Affinity DataKi:  72nMAssay Description:In vitro binding affinity towards Human 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109056(5-{2-[4-(1H-Pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydr...)
Affinity DataKi:  78nMAssay Description:Antagonism of 5-hydroxytryptamine 1A receptor determined in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109056(5-{2-[4-(1H-Pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydr...)
Affinity DataKi:  387nMAssay Description:Affinity for HC Serotonin transporter determined in vitro by incubating compound and [3H]-5-HT with human carcinoma (Jar cells), previously treated w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109056(5-{2-[4-(1H-Pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydr...)
Affinity DataIC50:  90nMAssay Description:Antagonism of 5-hydroxytryptamine 1A receptor determined in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109056(5-{2-[4-(1H-Pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydr...)
Affinity DataIC50:  90nMAssay Description:In vitro binding affinity towards Human 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed