BDBM50112219 3-(4-Methoxy-phenyl)-1-methyl-5-thiophen-3-yl-1H-[2,4']bipyridinyl-6-one::CHEMBL59197

SMILES COc1ccc(cc1)-c1cc(-c2ccsc2)c(=O)n(C)c1-c1ccncc1

InChI Key InChIKey=COKSTUDOWROCJE-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50112219   

TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112219(3-(4-Methoxy-phenyl)-1-methyl-5-thiophen-3-yl-1H-[...)
Affinity DataKi:  12nMAssay Description:Binding affinity by displacement of [3H]-Ro-15-1788 from recombinant human gamma-aminobutyric-acid A receptor alpha3,beta3,gamma2 stably expressed in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112219(3-(4-Methoxy-phenyl)-1-methyl-5-thiophen-3-yl-1H-[...)
Affinity DataKi:  39nMAssay Description:Inhibition of [3H]-Ro-15-1788 binding to human GABA A receptor (alpha1-beta3-gamma2) stably expressed in L(tk-) cells.More data for this Ligand-Target Pair
Target InfoGoogleScholar
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112219(3-(4-Methoxy-phenyl)-1-methyl-5-thiophen-3-yl-1H-[...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]-Ro-15-1788 from human Gamma-aminobutyric-acid A receptor alpha2-beta3-gamma2 stably expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112219(3-(4-Methoxy-phenyl)-1-methyl-5-thiophen-3-yl-1H-[...)
Affinity DataKi:  450nMAssay Description:Inhibition of [3H]-Ro-15-1788 binding to human GABA A receptor (alpha5-beta3-gamma2) stably expressed in L(tk-) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed