BDBM50112391 1-(3-Chloro-phenyl)-4-{3-[6-(4-trifluoromethoxy-phenyl)-pyridin-3-ylmethyl]-3H-imidazol-4-ylmethyl}-piperazin-2-one::CHEMBL23219

SMILES FC(F)(F)Oc1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cn1

InChI Key InChIKey=UUVHQULSIKGMES-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50112391   

LigandPNGBDBM50112391(1-(3-Chloro-phenyl)-4-{3-[6-(4-trifluoromethoxy-ph...)
Affinity DataIC50:  560nMAssay Description:Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112391(1-(3-Chloro-phenyl)-4-{3-[6-(4-trifluoromethoxy-ph...)
Affinity DataIC50:  52nMAssay Description:Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed