BDBM50113964 CHEMBL3605508

SMILES Nc1ccccc1NC(=O)c1ccc(CNC2=N[C@H](Cc3c[nH]cn3)CO2)cc1

InChI Key InChIKey=KKWSSPSMAXPDHE-QGZVFWFLSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50113964   

TargetHistone deacetylase 1(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50113964(CHEMBL3605508)
Affinity DataIC50:  130nMAssay Description:Inhibition of C-flagged recombinant HDAC1 (unknown origin) pre-incubated for 1 hr before substrate addition by homogeneous fluorogenic HDAC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50113964(CHEMBL3605508)
Affinity DataIC50:  1.13E+5nMAssay Description:Inhibition of His-flagged recombinant HDAC8 (unknown origin) expressed in Escherichia coli BL21 pre-incubated for 15 mins before substrate addition b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50113964(CHEMBL3605508)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant HDAC3/NCOR2 (unknown origin) pre-incubated for 3 hrs before substrate addition by homogeneous fluorogenic HDAC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50113964(CHEMBL3605508)
Affinity DataIC50:  290nMAssay Description:Inhibition of His-tagged recombinant HDAC2 (1 to 488 residues) (unknown origin) pre-incubated for 3 hrs before substrate addition by homogeneous fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed