BDBM50115295 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (4-nitro-phenyl)-amide::4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (4-nitro-phenyl)-amide(KN1022)::CHEMBL99743

SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)[N+]([O-])=O)c2cc1OC

InChI Key InChIKey=ZIFCMJKHIXABHJ-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50115295   

TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115295(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  890nMAssay Description:Inhibition of Platelet-derived growth factor receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50115295(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  700nMAssay Description:Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115295(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of MKK-3, Mitogen activated protein kinase kinase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115295(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of MKK-6, Mitogen activated protein kinase kinase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115295(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  390nMAssay Description:Inhibition of Mast/stem cell growth factor receptor (c-Kit kinase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115295(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115295(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  700nMAssay Description:Inhibition of Platelet-derived growth factor receptor beta phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115295(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 2 (VEGFR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115295(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  240nMAssay Description:Inhibition of Platelet-derived growth factor receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115295(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115295(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115295(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of MEK, Mitogen activated protein kinase kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115295(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Extracellular signal-regulated kinase 2 (Erk2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115295(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibitino of c-Jun N-terminal kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115295(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  700nMAssay Description:Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115295(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  700nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115295(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of Flt3 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed