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BDBM50117913 (E)-1-((5-(4-chlorophenyl)furan-2-yl)methyleneamino)-3-(4-(4-methylpiperazin-1-yl)butyl)imidazolidine-2,4-dione::1-{[1-[5-(4-Chloro-phenyl)-furan-2-yl]-meth-(E)-ylidene]-amino}-3-[4-(4-methyl-piperazin-1-yl)-butyl]-imidazolidine-2,4-dione::1-{[5-(4-Chloro-phenyl)-furan-2-ylmethylene]-amino}-3-[4-(4-methyl-piperazin-1-yl)-butyl]-imidazolidine-2,4-dione(Azimilide)::AZIMILIDE::AZIMILIDE DIHYDROCHLORIDE::CHEMBL123558

SMILES: CN1CCN(CCCCn2c(O)cn(N=Cc3ccc(o3)-c3ccc(Cl)cc3)c2=O)CC1

InChI Key: InChIKey=AFGPVGJVUMWQDE-UHFFFAOYSA-N

Data: 10 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50117913   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50117913
PNG
((E)-1-((5-(4-chlorophenyl)furan-2-yl)methyleneamin...)
Show SMILES CN1CCN(CCCCn2c(O)cn(N=Cc3ccc(o3)-c3ccc(Cl)cc3)c2=O)CC1
Show InChI InChI=1S/C23H28ClN5O3/c1-26-12-14-27(15-13-26)10-2-3-11-28-22(30)17-29(23(28)31)25-16-20-8-9-21(32-20)18-4-6-19(24)7-5-18/h4-9,16-17,30H,2-3,10-15H2,1H3
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PubMed
n/an/a 562n/an/an/an/an/an/a



TCG Lifesciences Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Eur J Med Chem 46: 618-30 (2011)


Article DOI: 10.1016/j.ejmech.2010.11.042
BindingDB Entry DOI: 10.7270/Q2WQ052W
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50117913
PNG
((E)-1-((5-(4-chlorophenyl)furan-2-yl)methyleneamin...)
Show SMILES CN1CCN(CCCCn2c(O)cn(N=Cc3ccc(o3)-c3ccc(Cl)cc3)c2=O)CC1
Show InChI InChI=1S/C23H28ClN5O3/c1-26-12-14-27(15-13-26)10-2-3-11-28-22(30)17-29(23(28)31)25-16-20-8-9-21(32-20)18-4-6-19(24)7-5-18/h4-9,16-17,30H,2-3,10-15H2,1H3
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n/an/a 180n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50117913
PNG
((E)-1-((5-(4-chlorophenyl)furan-2-yl)methyleneamin...)
Show SMILES CN1CCN(CCCCn2c(O)cn(N=Cc3ccc(o3)-c3ccc(Cl)cc3)c2=O)CC1
Show InChI InChI=1S/C23H28ClN5O3/c1-26-12-14-27(15-13-26)10-2-3-11-28-22(30)17-29(23(28)31)25-16-20-8-9-21(32-20)18-4-6-19(24)7-5-18/h4-9,16-17,30H,2-3,10-15H2,1H3
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n/an/a 240n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50117913
PNG
((E)-1-((5-(4-chlorophenyl)furan-2-yl)methyleneamin...)
Show SMILES CN1CCN(CCCCn2c(O)cn(N=Cc3ccc(o3)-c3ccc(Cl)cc3)c2=O)CC1
Show InChI InChI=1S/C23H28ClN5O3/c1-26-12-14-27(15-13-26)10-2-3-11-28-22(30)17-29(23(28)31)25-16-20-8-9-21(32-20)18-4-6-19(24)7-5-18/h4-9,16-17,30H,2-3,10-15H2,1H3
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n/an/a 1.41E+3n/an/an/an/an/an/a



Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Inhibition of human Potassium channel HERG expressed in mammalian cells


Bioorg Med Chem Lett 13: 2773-5 (2003)


Article DOI: 10.1016/s0960-894x(03)00492-x
BindingDB Entry DOI: 10.7270/Q2QZ2BGZ
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50117913
PNG
((E)-1-((5-(4-chlorophenyl)furan-2-yl)methyleneamin...)
Show SMILES CN1CCN(CCCCn2c(O)cn(N=Cc3ccc(o3)-c3ccc(Cl)cc3)c2=O)CC1
Show InChI InChI=1S/C23H28ClN5O3/c1-26-12-14-27(15-13-26)10-2-3-11-28-22(30)17-29(23(28)31)25-16-20-8-9-21(32-20)18-4-6-19(24)7-5-18/h4-9,16-17,30H,2-3,10-15H2,1H3
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n/an/a 560n/an/an/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
K+ channel blocking activity in Chinese hamster ovary cells expressing HERG Kv11.1


J Med Chem 45: 3844-53 (2002)


Article DOI: 10.1021/jm0208875
BindingDB Entry DOI: 10.7270/Q2NC61X3
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50117913
PNG
((E)-1-((5-(4-chlorophenyl)furan-2-yl)methyleneamin...)
Show SMILES CN1CCN(CCCCn2c(O)cn(N=Cc3ccc(o3)-c3ccc(Cl)cc3)c2=O)CC1
Show InChI InChI=1S/C23H28ClN5O3/c1-26-12-14-27(15-13-26)10-2-3-11-28-22(30)17-29(23(28)31)25-16-20-8-9-21(32-20)18-4-6-19(24)7-5-18/h4-9,16-17,30H,2-3,10-15H2,1H3
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n/an/a 562n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state


Bioorg Med Chem Lett 15: 1737-41 (2005)


Article DOI: 10.1016/j.bmcl.2005.01.008
BindingDB Entry DOI: 10.7270/Q2FT8NCR
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50117913
PNG
((E)-1-((5-(4-chlorophenyl)furan-2-yl)methyleneamin...)
Show SMILES CN1CCN(CCCCn2c(O)cn(N=Cc3ccc(o3)-c3ccc(Cl)cc3)c2=O)CC1
Show InChI InChI=1S/C23H28ClN5O3/c1-26-12-14-27(15-13-26)10-2-3-11-28-22(30)17-29(23(28)31)25-16-20-8-9-21(32-20)18-4-6-19(24)7-5-18/h4-9,16-17,30H,2-3,10-15H2,1H3
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n/an/a 562n/an/an/an/an/an/a



CASMedChem Laboratory

Curated by ChEMBL


Assay Description
Inhibition of human ERG in MCF7 cells


Eur J Med Chem 44: 1926-32 (2009)


Article DOI: 10.1016/j.ejmech.2008.11.009
BindingDB Entry DOI: 10.7270/Q2TM7CCD
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50117913
PNG
((E)-1-((5-(4-chlorophenyl)furan-2-yl)methyleneamin...)
Show SMILES CN1CCN(CCCCn2c(O)cn(N=Cc3ccc(o3)-c3ccc(Cl)cc3)c2=O)CC1
Show InChI InChI=1S/C23H28ClN5O3/c1-26-12-14-27(15-13-26)10-2-3-11-28-22(30)17-29(23(28)31)25-16-20-8-9-21(32-20)18-4-6-19(24)7-5-18/h4-9,16-17,30H,2-3,10-15H2,1H3
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n/an/a 1.41E+3n/an/an/an/an/an/a



Reverse proteomics research institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against potassium channel HERG


Bioorg Med Chem Lett 15: 2886-90 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.080
BindingDB Entry DOI: 10.7270/Q29S1S7C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50117913
PNG
((E)-1-((5-(4-chlorophenyl)furan-2-yl)methyleneamin...)
Show SMILES CN1CCN(CCCCn2c(O)cn(N=Cc3ccc(o3)-c3ccc(Cl)cc3)c2=O)CC1
Show InChI InChI=1S/C23H28ClN5O3/c1-26-12-14-27(15-13-26)10-2-3-11-28-22(30)17-29(23(28)31)25-16-20-8-9-21(32-20)18-4-6-19(24)7-5-18/h4-9,16-17,30H,2-3,10-15H2,1H3
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n/an/a 1.41E+3n/an/an/an/an/an/a



Hoffmann-La Roche

Curated by ChEMBL


Assay Description
Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique


Bioorg Med Chem 16: 6252-60 (2008)


Article DOI: 10.1016/j.bmc.2008.04.028
BindingDB Entry DOI: 10.7270/Q25D8T25
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50117913
PNG
((E)-1-((5-(4-chlorophenyl)furan-2-yl)methyleneamin...)
Show SMILES CN1CCN(CCCCn2c(O)cn(N=Cc3ccc(o3)-c3ccc(Cl)cc3)c2=O)CC1
Show InChI InChI=1S/C23H28ClN5O3/c1-26-12-14-27(15-13-26)10-2-3-11-28-22(30)17-29(23(28)31)25-16-20-8-9-21(32-20)18-4-6-19(24)7-5-18/h4-9,16-17,30H,2-3,10-15H2,1H3
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n/an/a 400n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibitory concentration against IKr potassium channel


Bioorg Med Chem Lett 14: 4771-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.06.070
BindingDB Entry DOI: 10.7270/Q208661K
More data for this
Ligand-Target Pair