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BDBM50118173 CHEMBL3613003

InChI string: InChI=1S/C10H11N3O3/c1-15-9-12-13(10(14)16-9)6-7-3-2-4-8(11)5-7/h2-5H,6,11H2,1H3

SMILES: COc1nn(Cc2cccc(N)c2)c(=O)o1

InChI Key: InChIKey=QGFPZGVBASJTKW-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50118173   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monoacylglycerol lipase ABHD6


(Homo sapiens)
BDBM50118173
PNG
(CHEMBL3613003)
Show SMILES COc1nn(Cc2cccc(N)c2)c(=O)o1
Show InChI InChI=1S/C10H11N3O3/c1-15-9-12-13(10(14)16-9)6-7-3-2-4-8(11)5-7/h2-5H,6,11H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 3.63E+3n/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Inhibition of human ABHD6 expressed in HEK293 cells at 1 uM pre-incubated for 10 mins before 2-AG substrate addition followed by rapid 40 fold compou...


Bioorg Med Chem 23: 6335-45 (2015)

More data for this
Ligand-Target Pair
Monoacylglycerol lipase ABHD6


(Homo sapiens)
BDBM50118173
PNG
(CHEMBL3613003)
Show SMILES COc1nn(Cc2cccc(N)c2)c(=O)o1
Show InChI InChI=1S/C10H11N3O3/c1-15-9-12-13(10(14)16-9)6-7-3-2-4-8(11)5-7/h2-5H,6,11H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 3.80E+3n/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Inhibition of human ABHD6 expressed in HEK293 cells at 1 uM pre-incubated for 10 mins before 2-AG substrate addition followed by rapid 40 fold compou...


Bioorg Med Chem 23: 6335-45 (2015)

More data for this
Ligand-Target Pair
Monoacylglycerol lipase ABHD6


(Homo sapiens)
BDBM50118173
PNG
(CHEMBL3613003)
Show SMILES COc1nn(Cc2cccc(N)c2)c(=O)o1
Show InChI InChI=1S/C10H11N3O3/c1-15-9-12-13(10(14)16-9)6-7-3-2-4-8(11)5-7/h2-5H,6,11H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 4.07E+3n/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Inhibition of human ABHD6 expressed in HEK293 cells at 1 uM pre-incubated for 10 mins before 2-AG substrate addition followed by rapid 40 fold compou...


Bioorg Med Chem 23: 6335-45 (2015)

More data for this
Ligand-Target Pair
Monoacylglycerol lipase ABHD6


(Homo sapiens)
BDBM50118173
PNG
(CHEMBL3613003)
Show SMILES COc1nn(Cc2cccc(N)c2)c(=O)o1
Show InChI InChI=1S/C10H11N3O3/c1-15-9-12-13(10(14)16-9)6-7-3-2-4-8(11)5-7/h2-5H,6,11H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 219n/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Inhibition of human ABHD6 expressed in HEK293 cells assessed as reduction in glycerol production from 1-AG hydrolysis pre-incubated for 30 mins befor...


Bioorg Med Chem 23: 6335-45 (2015)

More data for this
Ligand-Target Pair
Monoacylglycerol lipase ABHD6


(Homo sapiens)
BDBM50118173
PNG
(CHEMBL3613003)
Show SMILES COc1nn(Cc2cccc(N)c2)c(=O)o1
Show InChI InChI=1S/C10H11N3O3/c1-15-9-12-13(10(14)16-9)6-7-3-2-4-8(11)5-7/h2-5H,6,11H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 3.31E+3n/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Inhibition of human ABHD6 expressed in HEK293 cells at 1 uM pre-incubated for 10 mins before 2-AG substrate addition followed by rapid 40 fold compou...


Bioorg Med Chem 23: 6335-45 (2015)

More data for this
Ligand-Target Pair
Monoacylglycerol lipase ABHD6


(Homo sapiens)
BDBM50118173
PNG
(CHEMBL3613003)
Show SMILES COc1nn(Cc2cccc(N)c2)c(=O)o1
Show InChI InChI=1S/C10H11N3O3/c1-15-9-12-13(10(14)16-9)6-7-3-2-4-8(11)5-7/h2-5H,6,11H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 216n/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Inhibition of human ABHD6 expressed in HEK293 cells assessed as reduction in glycerol production from 1-AG hydrolysis pre-incubated for 30 mins befor...


Bioorg Med Chem 23: 6335-45 (2015)

More data for this
Ligand-Target Pair