BDBM50118690 3-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]oxazin-6-yl)-5-fluoro-benzonitrile::3-(4,4-dimethyl-2-oxo-2,4-dihydro-1H-benzo[d][1,3]oxazin-6-yl)-5-fluorobenzonitrile::CHEMBL136322

SMILES CC1(C)OC(=O)Nc2ccc(cc12)-c1cc(F)cc(c1)C#N

InChI Key InChIKey=KVMSWMUZFCLLFV-UHFFFAOYSA-N

Data  9 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50118690   

TargetProgesterone receptor(Homo sapiens (Human))
Women'S Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50118690(3-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Affinity DataIC50:  15.9nMAssay Description:Antagonist activity against the Progesterone Receptor (PR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Women'S Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50118690(3-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Affinity DataEC50:  90nMAssay Description:Agonist activity against progesterone receptor (PR) in an alkaline phosphatase assay in the T47D human breast carcinoma cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Women'S Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50118690(3-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Affinity DataIC50:  1.76E+3nMAssay Description:Antagonist activity against the Glucocorticoid Receptor (GR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Women'S Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50118690(3-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Affinity DataIC50:  2.37E+3nMAssay Description:Antagonist activity against the Mineralocorticoid Receptor (MR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Women'S Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50118690(3-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Affinity DataIC50:  1.80E+3nMAssay Description:Antagonist activity at human GR assessed as reduction in dexamethasone-induced transactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Women'S Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50118690(3-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Affinity DataIC50:  1.29E+3nMAssay Description:Antagonist activity against the Androgen Receptor (AR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Women'S Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50118690(3-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Affinity DataIC50:  90nMAssay Description:Antagonist activity at progesterone receptor assessed as alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Women'S Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50118690(3-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Affinity DataIC50:  16nMAssay Description:Antagonist activity at human PRB expressed in African green monkey CV1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Women'S Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50118690(3-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Affinity DataIC50:  1.30E+3nMAssay Description:Antagonist activity at human AR assessed as reduction in DHT-induced transactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Women'S Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50118690(3-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Affinity DataIC50:  15.9nMAssay Description:Antagonist activity against progesterone receptor (PR) in an assay using PRE-luciferase plasmid co-transfected CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed