BDBM50119583 CHEMBL3617744::US10413545, Compound 53::US9718813, Compound 53
SMILES Cn1ncc2cc(ccc12)-c1ccc(C2=NC(C)(C)C(=O)N2C[C@@H]2CCN(C2)C(=O)C2CC2)c(F)c1
InChI Key InChIKey=HUYQXQKANYTHPW-QGZVFWFLSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50119583
Affinity DataIC50: 93nMAssay Description:Inhibition of fatty acid synthase (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 324nMAssay Description:Inhibition of fatty acid synthase keto-reductase domain (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 93.3nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
Affinity DataIC50: 324nMpH: 7.5 T: 2°CAssay Description:10 μL assay buffer (100 mM KH2PO4 pH 7.5) was added to a 384-well clear plate (costar 3702). 0.3 μL compound (at concentrations of 30 μ...More data for this Ligand-Target Pair
Affinity DataIC50: 93.3nMpH: 7.5 T: 2°CAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair