BDBM50119621 CHEMBL3618245

SMILES COc1ncc(Nc2nc3ccc(cn3c2-c2nc(C)nc(N)n2)C(C)(C)O)cc1F

InChI Key InChIKey=IYNZEXDVRAZUPW-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50119621   

LigandPNGBDBM50119621(CHEMBL3618245)
Affinity DataKi:  0.600nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119621(CHEMBL3618245)
Affinity DataKi:  5.30nMAssay Description:Inhibition of PI3Kgamma (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119621(CHEMBL3618245)
Affinity DataKi:  11nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119621(CHEMBL3618245)
Affinity DataKi:  17nMAssay Description:Inhibition of PI3Kbeta (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50119621(CHEMBL3618245)
Affinity DataIC50:  206nMAssay Description:Inhibition of GST-tagged mTOR (1360 to 2549 residues) (unknown origin) using Ulight 4eBP1 peptide incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119621(CHEMBL3618245)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of PI3Kalpha in human U87MG cells assessed as reduction in AKT Ser473 phosphorylation incubated for 2 hrs followed by compound wahout by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed