BDBM50120422 CHEMBL3617852

SMILES COc1ccc(cc1)S(=O)(=O)Nc1ccc(N(CC(O)=O)S(=O)(=O)c2ccc(OC)cc2)c2ccccc12

InChI Key InChIKey=NVQFDGYHTTZFJR-UHFFFAOYSA-N

Data  2 IC50  1 Kd  1 EC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50120422   

TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50120422(CHEMBL3617852)
Affinity DataEC50:  29nMAssay Description:Inhibition of Keap1 (unknown origin) interaction to Nrf2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50120422(CHEMBL3617852)
Affinity DataKd:  110nMAssay Description:Inhibition of Keap1-Nrf2 (unknown origin) protein-protein interaction by SPR assayMore data for this Ligand-Target Pair
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50120422(CHEMBL3617852)
Affinity DataIC50:  61nMAssay Description:Inhibition of Keap1-Nrf2 (unknown origin) protein-protein interaction expressed in Escherichia coli BL21 codon plus cells using FITC-beta-DEETGEF-OH ...More data for this Ligand-Target Pair
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50120422(CHEMBL3617852)
Affinity DataIC50:  110nMAssay Description:Binding affinity to the Keap1 (321 to 609 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by surface plasmon resonance assa...More data for this Ligand-Target Pair