BDBM50121362 CHEMBL3622107::US9751881, Example 9

SMILES Cc1nc(ccc1C#N)N1CCC2(C1)CCN(C[C@H](O)c1ccc3C(=O)OCc3c1C)CC2

InChI Key InChIKey=DAEXRDGKBMPMOR-QHCPKHFHSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50121362   

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50121362(CHEMBL3622107 | US9751881, Example 9)
Affinity DataIC50:  14nMAssay Description:Assay Protocol: The ROMK channel functional thallium flux assay was performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells were ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50121362(CHEMBL3622107 | US9751881, Example 9)
Affinity DataIC50:  14nMAssay Description:Inhibition of human Kir1.1 expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed