BDBM50121589 4-(2-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-[1,3,5]triazin-2-ylamino}-ethyl)-phenol::CHEMBL347560

SMILES CN(CCCc1ccc(Cl)cc1)c1nc(NCCc2ccc(O)cc2)nc(n1)N1CCN(CCO)CC1

InChI Key InChIKey=FFIKIRZWTPILOL-UHFFFAOYSA-N

Data  2 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50121589   

TargetEstrogen receptor beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50121589(4-(2-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino...)
Affinity DataKi:  15nMAssay Description:In vitro binding affinity towards human Estrogen receptor 2 using [3H]-17-beta-estradiol as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50121589(4-(2-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino...)
Affinity DataKi:  395nMAssay Description:In vitro binding affinity towards human Estrogen receptor alpha using [3H]-17-beta-estradiol as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50121589(4-(2-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibition of 1 nM 17-beta-estradiol induced transcriptional activation in T47D cells expressing estrogen receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50121589(4-(2-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino...)
Affinity DataEC50:  180nMAssay Description:Agonist effect on transcriptional activation in T47D cells expressing estrogen receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50121589(4-(2-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino...)
Affinity DataIC50:  30nMAssay Description:In vitro inhibition of transcriptional activation induced by 1 nM 17-beta estradiol in T47D cells expressing estrogen receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed