BDBM50122843 6-Thiophen-3-yl-3-(3-trifluoromethyl-phenyl)-4H-pyrazolo[1,5-a]pyrimidin-7-one::CHEMBL322313

SMILES FC(F)(F)c1cccc(c1)-c1c[nH]n2c1ncc(-c1ccsc1)c2=O

InChI Key InChIKey=DTPGJMFWKWJQOR-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50122843   

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rattus norvegicus (Rat))
University Of Firenze

Curated by ChEMBL
LigandPNGBDBM50122843(6-Thiophen-3-yl-3-(3-trifluoromethyl-phenyl)-4H-py...)
Affinity DataKi:  10nMAssay Description:Binding affinity for recombinant rat GABA-A receptor alpha1-beta2-gamma2 subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2(Rattus norvegicus (Rat))
University Of Firenze

Curated by ChEMBL
LigandPNGBDBM50122843(6-Thiophen-3-yl-3-(3-trifluoromethyl-phenyl)-4H-py...)
Affinity DataKi:  89nMAssay Description:Binding affinity for recombinant rat GABA-A receptor alpha3-beta2-gamma2 subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-2(Rattus norvegicus (Rat))
University Of Firenze

Curated by ChEMBL
LigandPNGBDBM50122843(6-Thiophen-3-yl-3-(3-trifluoromethyl-phenyl)-4H-py...)
Affinity DataKi:  207nMAssay Description:Binding affinity for recombinant rat GABA-A receptor alpha5-beta3-gamma2 subunits expresssed in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Rattus norvegicus (Rat))
University Of Firenze

Curated by ChEMBL
LigandPNGBDBM50122843(6-Thiophen-3-yl-3-(3-trifluoromethyl-phenyl)-4H-py...)
Affinity DataKi:  540nMAssay Description:Binding affinity for recombinant rat GABA-A receptor alpha2-beta2-gamma2 subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed