BDBM50122913 6-[2-(2,4-Difluoro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-2-o-tolyl-2H-pyridazin-3-one::CHEMBL118187

SMILES Cc1ccccc1-n1nc(ccc1=O)-c1c(nc2ccccn12)-c1ccc(F)cc1F

InChI Key InChIKey=NVYYXGQQJYMXCV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50122913   

TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122913(6-[2-(2,4-Difluoro-phenyl)-imidazo[1,2-a]pyridin-3...)
Affinity DataIC50:  68nMAssay Description:Inhibition of Tumor necrosis factor alpha release from LPS-induced THP-1 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122913(6-[2-(2,4-Difluoro-phenyl)-imidazo[1,2-a]pyridin-3...)
Affinity DataIC50:  26nMAssay Description:Tested in vitro for filter plate binding versus gamma-[33P]ATP in active recombinant murine FLAG-P38 alpha fusion protein (GST-Activating transcripti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122913(6-[2-(2,4-Difluoro-phenyl)-imidazo[1,2-a]pyridin-3...)
Affinity DataIC50:  140nMAssay Description:Displacement of [gamma-33P]-ATP binding from active recombinant murine FLAG-Mitogen-activated protein kinase p38 beta fusion protein (GST-ATF2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122913(6-[2-(2,4-Difluoro-phenyl)-imidazo[1,2-a]pyridin-3...)
Affinity DataIC50:  870nMAssay Description:Inhibition of LPS-induced p38-related Tumor necrosis factor alpha release in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed