BDBM50122918 2-(2,6-Dichloro-phenyl)-6-[2-(2,4-difluoro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-2H-pyridazin-3-one::CHEMBL333243

SMILES Fc1ccc(-c2nc3ccccn3c2-c2ccc(=O)n(n2)-c2c(Cl)cccc2Cl)c(F)c1

InChI Key InChIKey=XQOXBLZAGOVRCZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50122918   

TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122918(2-(2,6-Dichloro-phenyl)-6-[2-(2,4-difluoro-phenyl)...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of LPS-induced p38-related Tumor necrosis factor alpha release in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122918(2-(2,6-Dichloro-phenyl)-6-[2-(2,4-difluoro-phenyl)...)
Affinity DataIC50:  22nMAssay Description:Tested in vitro for filter plate binding versus gamma-[33P]ATP in active recombinant murine FLAG-P38 alpha fusion protein (GST-Activating transcripti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122918(2-(2,6-Dichloro-phenyl)-6-[2-(2,4-difluoro-phenyl)...)
Affinity DataIC50:  112nMAssay Description:Displacement of [gamma-33P]-ATP binding from active recombinant murine FLAG-Mitogen-activated protein kinase p38 beta fusion protein (GST-ATF2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed