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BDBM50129894 6-{3-[2-(2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-propylamino}-nicotinonitrile::CHEMBL318775

SMILES: O=C(CNCCCNc1ccc(cn1)C#N)N1CCC[C@H]1C#N

InChI Key: InChIKey=GOBBLEVRSLGSOV-AWEZNQCLSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50129894   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50129894
PNG
(6-{3-[2-(2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino...)
Show SMILES O=C(CNCCCNc1ccc(cn1)C#N)N1CCC[C@H]1C#N
Show InChI InChI=1S/C16H20N6O/c17-9-13-4-5-15(21-11-13)20-7-2-6-19-12-16(23)22-8-1-3-14(22)10-18/h4-5,11,14,19H,1-3,6-8,12H2,(H,20,21)/t14-/m0/s1
PDB
MMDB

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Similars

Article
PubMed
n/an/a 102n/an/an/an/an/an/a



Novartis Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of human dipeptidyl peptidase IV (DPP IV) obtained from human colonic carcinoma cells


J Med Chem 46: 2774-89 (2003)


Article DOI: 10.1021/jm030091l
BindingDB Entry DOI: 10.7270/Q20001HR
More data for this
Ligand-Target Pair