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BDBM50130693 CGP-57380::CHEMBL1240885

SMILES: Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12

InChI Key: InChIKey=UQPMANVRZYYQMD-UHFFFAOYSA-N

Data: 4 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50130693   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50130693
PNG
(CGP-57380 | CHEMBL1240885)
Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12
Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
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PubMed
340n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 90 mins by ...


Eur J Med Chem 103: 539-50 (2015)


Article DOI: 10.1016/j.ejmech.2015.09.008
BindingDB Entry DOI: 10.7270/Q2S184B8
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50130693
PNG
(CGP-57380 | CHEMBL1240885)
Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12
Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
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1.01E+3n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1a (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after ...


Eur J Med Chem 103: 539-50 (2015)


Article DOI: 10.1016/j.ejmech.2015.09.008
BindingDB Entry DOI: 10.7270/Q2S184B8
More data for this
Ligand-Target Pair
CDK2/Cyclin A/Cyclin A1


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130693
PNG
(CGP-57380 | CHEMBL1240885)
Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12
Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclinA (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured...


Eur J Med Chem 103: 539-50 (2015)


Article DOI: 10.1016/j.ejmech.2015.09.008
BindingDB Entry DOI: 10.7270/Q2S184B8
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM50130693
PNG
(CGP-57380 | CHEMBL1240885)
Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12
Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of CDK9/cyclinT1 (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measure...


Eur J Med Chem 103: 539-50 (2015)


Article DOI: 10.1016/j.ejmech.2015.09.008
BindingDB Entry DOI: 10.7270/Q2S184B8
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50130693
PNG
(CGP-57380 | CHEMBL1240885)
Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12
Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
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Article
PubMed
n/an/a 870n/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1a (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after ...


Eur J Med Chem 103: 539-50 (2015)


Article DOI: 10.1016/j.ejmech.2015.09.008
BindingDB Entry DOI: 10.7270/Q2S184B8
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50130693
PNG
(CGP-57380 | CHEMBL1240885)
Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12
Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
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CHEMBL
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UniChem

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Article
PubMed
n/an/a 1.60E+3n/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 45 mins by ...


Eur J Med Chem 103: 539-50 (2015)


Article DOI: 10.1016/j.ejmech.2015.09.008
BindingDB Entry DOI: 10.7270/Q2S184B8
More data for this
Ligand-Target Pair