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BDBM50131440 10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulfinyl)-10H-phenothiazine::2-Methanesulfinyl-10-[2-(1-methyl-piperidin-2-yl)-ethyl]-10H-phenothiazine::CHEMBL1088::MESORIDAZINE::NC-123::Serentil::TPS-23

SMILES: CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O

InChI Key: InChIKey=SLVMESMUVMCQIY-UHFFFAOYSA-N

Data: 32 KI  5 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 37 hits for monomerid = 50131440   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H1 receptor


(Homo sapiens (human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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PubMed
1.80n/an/an/an/an/an/an/an/a



Mayo Clinic and Foundation

Curated by PDSP Ki Database




Eur J Pharmacol 103: 197-204 (1984)

More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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1.81n/an/an/an/an/an/an/an/a



Mayo Clinic and Foundation

Curated by PDSP Ki Database




Ann N Y Acad Sci 537: 435-42 (1988)

More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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2n/an/an/an/an/an/an/an/a



Mayo Clinic and Foundation

Curated by PDSP Ki Database




Eur J Pharmacol 103: 197-204 (1984)

More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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2n/an/an/an/an/an/an/an/a



Mayo Clinic and Foundation

Curated by PDSP Ki Database




Ann N Y Acad Sci 537: 435-42 (1988)

More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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PubMed
2.60n/an/an/an/an/an/an/an/a



ACADIA Pharmaceuticals

Curated by PDSP Ki Database




J Pharmacol Exp Ther 315: 1278-87 (2005)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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4.30n/an/an/an/an/an/an/an/a



ACADIA Pharmaceuticals

Curated by PDSP Ki Database




J Pharmacol Exp Ther 315: 1278-87 (2005)

More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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4.76n/an/an/an/an/an/an/an/a



Mayo Clinic and Foundation

Curated by PDSP Ki Database




Ann N Y Acad Sci 537: 435-42 (1988)

More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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5n/an/an/an/an/an/an/an/a



Case Western Reserve University

Curated by PDSP Ki Database




Psychopharmacology (Berl) 120: 365-8 (1995)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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6.30n/an/an/an/an/an/an/an/a



Case Western Reserve University

Curated by PDSP Ki Database




Psychopharmacology (Berl) 120: 365-8 (1995)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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6.30n/an/an/an/an/an/an/an/a



Case Western Reserve University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 268: 1403-10 (1994)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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6.30n/an/an/an/an/an/an/an/a



Stanford University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 260: 1361-5 (1992)

More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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7.94n/an/an/an/an/an/an/an/a



Case Western Reserve University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 268: 1403-10 (1994)

More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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9.10n/an/an/an/an/an/an/an/a



ACADIA Pharmaceuticals

Curated by PDSP Ki Database




J Pharmacol Exp Ther 315: 1278-87 (2005)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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10n/an/an/an/an/an/an/an/a



Mayo Clinic Jacksonville

Curated by PDSP Ki Database




J Pharmacol Exp Ther 260: 576-80 (1992)

More data for this
Ligand-Target Pair
Dopamine receptor


(RAT)
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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13.4n/an/an/an/an/an/an/an/a



Case Western Reserve University

Curated by PDSP Ki Database




Psychopharmacology (Berl) 120: 365-8 (1995)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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15n/an/an/an/an/an/an/an/a



Mayo Clinic Jacksonville

Curated by PDSP Ki Database




J Pharmacol Exp Ther 260: 576-80 (1992)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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18.9n/an/an/an/an/an/an/an/a



Mayo Clinic and Foundation

Curated by PDSP Ki Database




Ann N Y Acad Sci 537: 435-42 (1988)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(HUMAN M3)
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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19n/an/an/an/an/an/an/an/a



Mayo Clinic Jacksonville

Curated by PDSP Ki Database




J Pharmacol Exp Ther 260: 576-80 (1992)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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19n/an/an/an/an/an/an/an/a



Mayo Clinic and Foundation

Curated by PDSP Ki Database




Eur J Pharmacol 103: 197-204 (1984)

More data for this
Ligand-Target Pair
CHRM5


(Homo sapiens)
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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60n/an/an/an/an/an/an/an/a



Mayo Clinic Jacksonville

Curated by PDSP Ki Database




J Pharmacol Exp Ther 260: 576-80 (1992)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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69n/an/an/an/an/an/an/an/a



Mayo Clinic and Foundation

Curated by PDSP Ki Database




Eur J Pharmacol 103: 197-204 (1984)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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71.4n/an/an/an/an/an/an/an/a



Mayo Clinic and Foundation

Curated by PDSP Ki Database




Ann N Y Acad Sci 537: 435-42 (1988)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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73n/an/an/an/an/an/an/an/a



Case Western Reserve University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 268: 1403-10 (1994)

More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2c (5HT2A and 5HT2C)


(Rattus norvegicus (Rat))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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79n/an/an/an/an/an/an/an/a



Stanford University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 260: 1361-5 (1992)

More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2c (5HT2A and 5HT2C)


(Rattus norvegicus (Rat))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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79.4n/an/an/an/an/an/an/an/a



Case Western Reserve University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 268: 1403-10 (1994)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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90n/an/an/an/an/an/an/an/a



Mayo Clinic Jacksonville

Curated by PDSP Ki Database




J Pharmacol Exp Ther 260: 576-80 (1992)

More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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157n/an/an/an/an/an/an/an/a



Albany Medical College

Curated by PDSP Ki Database




J Pharmacol Exp Ther 295: 226-32 (2000)

More data for this
Ligand-Target Pair
HTR6


(RAT)
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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159n/an/an/an/an/an/an/an/a



Case Western Reserve University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 268: 1403-10 (1994)

More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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380n/an/an/an/an/an/an/an/a



University of Washington

Curated by PDSP Ki Database




J Neurochem 66: 47-56 (1996)

More data for this
Ligand-Target Pair
5-HT1


(Homo sapiens (human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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500n/an/an/an/an/an/an/an/a



Mayo Clinic and Foundation

Curated by PDSP Ki Database




Ann N Y Acad Sci 537: 435-42 (1988)

More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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1.60E+3n/an/an/an/an/an/an/an/a



Mayo Clinic and Foundation

Curated by PDSP Ki Database




Eur J Pharmacol 103: 197-204 (1984)

More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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1.61E+3n/an/an/an/an/an/an/an/a



Mayo Clinic and Foundation

Curated by PDSP Ki Database




Ann N Y Acad Sci 537: 435-42 (1988)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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n/an/a 550n/an/an/an/an/an/a



Reverse proteomics research institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against potassium channel HERG


Bioorg Med Chem Lett 15: 2886-90 (2005)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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n/an/a 320n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human ERG channel


J Med Chem 52: 4266-76 (2009)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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n/an/a 324n/an/an/an/an/an/a



Gedeon Richter Ltd

Curated by ChEMBL


Assay Description
Inhibition of human Potassium channel HERG expressed in mammalian cells


Bioorg Med Chem Lett 13: 2773-5 (2003)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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n/an/a 316n/an/an/an/an/an/a



TCG Lifesciences Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Eur J Med Chem 46: 618-30 (2011)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50131440
PNG
(10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulf...)
Show SMILES CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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n/an/a 324n/an/an/an/an/an/a



Hoffmann-La Roche

Curated by ChEMBL


Assay Description
Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique


Bioorg Med Chem 16: 6252-60 (2008)

More data for this
Ligand-Target Pair