BDBM50131774 CHEMBL2403769

SMILES C[C@]1(COCC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F

InChI Key InChIKey=BBTMSQSMAGSWCB-KRWDZBQOSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50131774   

TargetBeta-secretase 1(Mus musculus (Mouse))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50131774(CHEMBL2403769)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of BACE1 in mouse Neuro-2a cells expressing wild type human APP695 assessed as reduction in amyloid beta-42 production after 18 hrs by san...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50131774(CHEMBL2403769)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of BACE1 in human SKNBE2 cells expressing wild type human APP695 assessed as reduction in amyloid beta-42 production after 18 hrs by sandw...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50131774(CHEMBL2403769)
Affinity DataIC50:  22nMAssay Description:Inhibition of BACE1 (unknown origin) using APP Swedish mutant harboring Lys-Met/Asn-Leu mutation in beta-secretase cleavage site as substrate by FRET...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed