BDBM50134187 CHEMBL3735506::US11472795, Example C::US9611249, Compound 8
SMILES COCCN1CCC(CNC(=O)c2n[nH]c3ccc(cc23)-c2cccc(F)c2F)CC1
InChI Key InChIKey=QCLXNOBXQUWUEW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50134187
Affinity DataIC50: 220nMAssay Description:Inhibition of human recombinant ERK5 by LANCE assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Angelini
Curated by ChEMBL
Angelini
Curated by ChEMBL
Affinity DataIC50: 530nMAssay Description:Inhibition of human recombinant DYRK2 by LANCE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 530nMAssay Description:Inhibition of human recombinant GRK2 by LANCE assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Angelini Acraf
US Patent
Angelini Acraf
US Patent
Affinity DataIC50: 49.9nMAssay Description:Confirmation of interaction with the potassium channels of the compounds of the invention listed in the following Table 1 and of the comparison compo...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged GSK3beta (1 to 420 end residues) expressed in baculovirus expression system using u...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Angelini Acraf
US Patent
Angelini Acraf
US Patent
Affinity DataIC50: 44nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in tail current by measuring tail current amplitude measured after deploarizat...More data for this Ligand-Target Pair
Affinity DataIC50: 21.6nMAssay Description:The activity on human GSK-3β of the compounds of the invention listed in the following Table 1 and of the comparison compound C was assessed at ...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair