BDBM50134989 CHEMBL3746640
SMILES NC(=O)c1c(Oc2cccc(CNS(N)(=O)=O)c2)cc(F)c(F)c1Nc1ccc(I)cc1F
InChI Key InChIKey=KQYTZJXGFPXBER-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50134989
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Bayer HealthCare AG
Curated by ChEMBL
Bayer HealthCare AG
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Bayer HealthCare AG
Curated by ChEMBL
Bayer HealthCare AG
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of MEK1 in human HeLa-MaTu matched pair cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Bayer HealthCare AG
Curated by ChEMBL
Bayer HealthCare AG
Curated by ChEMBL
Affinity DataIC50: 8.70nMAssay Description:Inhibition of MEK1 in human HeLa-MaTu-ADR matched pair cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human carbonic anhydrase 2More data for this Ligand-Target Pair