BDBM50136486 CHEMBL405301::[(D)MeSer]3-[(40-OH) MeLeu]4-Cyclosporin A

SMILES CC[C@@H]1NC(=O)C([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)(C)O)N(C)C(=O)[C@@H](CO)N(C)C1=O)C(C)C

InChI Key InChIKey=XCXAXJCKONNWJE-HXEFTPTGSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50136486   

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Centre De Recherche De Paris

Curated by ChEMBL
LigandPNGBDBM50136486(CHEMBL405301 | [(D)MeSer]3-[(40-OH) MeLeu]4-Cyclos...)
Affinity DataIC50:  95nMAssay Description:In vitro inhibitory activity against HIV-1 RT in CEM4 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Centre De Recherche De Paris

Curated by ChEMBL
LigandPNGBDBM50136486(CHEMBL405301 | [(D)MeSer]3-[(40-OH) MeLeu]4-Cyclos...)
Affinity DataIC50:  783nMAssay Description:Immunosuppressive activity was measured by inhibition of the IL-2 production in Jurkat cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed