BDBM50136777 CHEMBL3753077

SMILES COc1ccc(cc1)C1(CNC(=O)c2ccc(NC(=O)c3ccco3)cc2)CCOCC1

InChI Key InChIKey=ZJZWZIXSGNFWQQ-UHFFFAOYSA-N

Data  10 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50136777   

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50136777(CHEMBL3753077)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human TNKS1 by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50136777(CHEMBL3753077)
Affinity DataIC50:  2.01E+3nMAssay Description:Inhibition of human TNKS2 by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50136777(CHEMBL3753077)
Affinity DataIC50:  1.82E+3nMAssay Description:Inhibition of human TNKS1 by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50136777(CHEMBL3753077)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human TNKS2 by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50136777(CHEMBL3753077)
Affinity DataIC50:  830nMAssay Description:Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails PubMedPDB3D3D Structure (crystal)

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50136777(CHEMBL3753077)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of TNKS2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMedPDB3D3D Structure (crystal)

TargetPoly [ADP-ribose] polymerase 1(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50136777(CHEMBL3753077)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50136777(CHEMBL3753077)
Affinity DataIC50:  850nMAssay Description:Maximum response (E max) against Histamine H1 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails PubMedPDB3D3D Structure (crystal)

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50136777(CHEMBL3753077)
Affinity DataIC50:  1.90E+3nMAssay Description:Apparent pA2 value of compound at 10 nM concentration of mepyramine in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails PubMedPDB3D3D Structure (crystal)

TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50136777(CHEMBL3753077)
Affinity DataIC50:  1.23E+3nMAssay Description:Inhibition of tankyrase in WNT3a-stimulated human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)