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BDBM50139758 (2-Naphthalen-2-yl-1-naphthalen-1-yl-2-oxo-ethyl)-phosphonic acid::1-(naphthalen-1-yl)-2-(naphthalen-2-yl)-2-oxoethylphosphonic acid::CHEMBL424224

SMILES: OP(O)(=O)C(C(=O)c1ccc2ccccc2c1)c1cccc2ccccc12

InChI Key: InChIKey=OFHMUASCSJJNNA-UHFFFAOYSA-N

Data: 2 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50139758   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostatic acid phosphatase


(Homo sapiens)
BDBM50139758
PNG
((2-Naphthalen-2-yl-1-naphthalen-1-yl-2-oxo-ethyl)-...)
Show SMILES OP(O)(=O)C(C(=O)c1ccc2ccccc2c1)c1cccc2ccccc12
Show InChI InChI=1S/C22H17O4P/c23-21(18-13-12-15-6-1-2-8-17(15)14-18)22(27(24,25)26)20-11-5-9-16-7-3-4-10-19(16)20/h1-14,22H,(H2,24,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
n/an/a 6.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for 50% of inhibition of Osteoclastic acid phosphatase (OAP) activity, determined using dose-response curve


Bioorg Med Chem Lett 5: 1801-1806 (1995)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50139758
PNG
((2-Naphthalen-2-yl-1-naphthalen-1-yl-2-oxo-ethyl)-...)
Show SMILES OP(O)(=O)C(C(=O)c1ccc2ccccc2c1)c1cccc2ccccc12
Show InChI InChI=1S/C22H17O4P/c23-21(18-13-12-15-6-1-2-8-17(15)14-18)22(27(24,25)26)20-11-5-9-16-7-3-4-10-19(16)20/h1-14,22H,(H2,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 4.10E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human Cathepsin G


J Med Chem 47: 769-87 (2004)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)