BDBM50140168 (E)-1-(2,4-dihydroxyphenyl)-3-(3-hydroxyphenyl)-2-propen-1-one (2)::(E)-3,2'',4''-Trihydroxychalcone::CHEMBL1083821

SMILES Oc1cccc(\C=C\C(=O)c2ccc(O)cc2O)c1

InChI Key InChIKey=WKMQGQZPDSFACZ-QPJJXVBHSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50140168   

TargetBeta-secretase 1(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

LigandPNGBDBM50140168((E)-1-(2,4-dihydroxyphenyl)-3-(3-hydroxyphenyl)-2-...)
Affinity DataIC50:  8.03E+3nMpH: 4.5 T: 2°CAssay Description:The assay based on fluorescenceresonance energy transfer was carried out with BACE1 enzyme at pH 4.5 with a substrate, H-Lys(DABSYL)-SEVNLDAEFR-Gin-(...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50140168((E)-1-(2,4-dihydroxyphenyl)-3-(3-hydroxyphenyl)-2-...)
Affinity DataIC50:  1.08E+5nMAssay Description:Inhibition of bovine milk xanthine oxidase pre-incubated for 30 mins followed by xanthine addition and measured every 30 secs for 5 mins by spectroph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50140168((E)-1-(2,4-dihydroxyphenyl)-3-(3-hydroxyphenyl)-2-...)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of bovine xanthine oxidase assessed as conversion of xanthine to uric acid by spectroscopic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed