BDBM50140813 4-[4-(2-Oxo-2-phenyl-ethyl)-piperazin-1-yl]-6,7,8,9-tetrahydro-pyrimido[4,5-b]indolizine-10-carbonitrile::CHEMBL27834

SMILES O=C(CN1CCN(CC1)c1ncnc2c(C#N)c3CCCCn3c12)c1ccccc1

InChI Key InChIKey=BREASPARKWKPHH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50140813   

TargetATP-dependent translocase ABCB1(Mus musculus)
Xenova

Curated by ChEMBL
LigandPNGBDBM50140813(4-[4-(2-Oxo-2-phenyl-ethyl)-piperazin-1-yl]-6,7,8,...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibitory activity against mouse transporter Pgp (P-glycoprotein) expressed in EMT6/AR1.0 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140813(4-[4-(2-Oxo-2-phenyl-ethyl)-piperazin-1-yl]-6,7,8,...)
Affinity DataIC50:  1.85E+3nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed