BDBM50140814 4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-yl}-2-pyridin-3-yl-6,7,8,9-tetrahydro-pyrimido[4,5-b]indolizine-10-carbonitrile::CHEMBL282819

SMILES Fc1ccc(CCN2CCN(CC2)c2nc(nc3c(C#N)c4CCCCn4c23)-c2cccnc2)cc1F

InChI Key InChIKey=WCEZPLUBCDVBMG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50140814   

TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
M.D. University

Curated by ChEMBL
LigandPNGBDBM50140814(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: <250nMAssay Description:Inhibitory concentration against multidrug resistance associated protein 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
M.D. University

Curated by ChEMBL
LigandPNGBDBM50140814(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50:  218nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed