BDBM50140818 4-(4-Phenethyl-piperazin-1-yl)-2-phenyl-6,7,8,9-tetrahydro-pyrimido[4,5-b]indolizine-10-carbonitrile::CHEMBL27497

SMILES N#Cc1c2CCCCn2c2c(nc(nc12)-c1ccccc1)N1CCN(CCc2ccccc2)CC1

InChI Key InChIKey=WAVIUTGGWQJYMD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50140818   

TargetATP-dependent translocase ABCB1(Mus musculus)
Xenova

Curated by ChEMBL
LigandPNGBDBM50140818(4-(4-Phenethyl-piperazin-1-yl)-2-phenyl-6,7,8,9-te...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibitory activity against mouse transporter Pgp (P-glycoprotein) expressed in EMT6/AR1.0 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140818(4-(4-Phenethyl-piperazin-1-yl)-2-phenyl-6,7,8,9-te...)
Affinity DataIC50:  715nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed