BDBM50141084 6-[4-(2-Dimethylamino-ethoxy)-naphthalen-1-yl]-pyridin-2-ylamine::CHEMBL43245

SMILES CN(C)CCOc1ccc(-c2cccc(N)n2)c2ccccc12

InChI Key InChIKey=WPECHTREAJBIKW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50141084   

TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141084(6-[4-(2-Dimethylamino-ethoxy)-naphthalen-1-yl]-pyr...)
Affinity DataIC50:  4.60E+3nMAssay Description:In vitro inhibition of human inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141084(6-[4-(2-Dimethylamino-ethoxy)-naphthalen-1-yl]-pyr...)
Affinity DataIC50:  5.79E+3nMAssay Description:In vitro inhibition of human endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141084(6-[4-(2-Dimethylamino-ethoxy)-naphthalen-1-yl]-pyr...)
Affinity DataIC50:  167nMAssay Description:In vitro inhibition of rat neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141084(6-[4-(2-Dimethylamino-ethoxy)-naphthalen-1-yl]-pyr...)
Affinity DataIC50:  220nMAssay Description:In vitro inhibition of human neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed