BDBM50141532 (E)-1-(4-Methoxy-phenyl)-3-phenyl-propenone::1-(4-Methoxy-phenyl)-3-phenyl-propenone::1-(4-methoxyphenyl)-3-phenylprop-2-en-1-one (6)::CHEMBL34398::E)-1-(4-methoxyphenyl)-3-phenylprop-2-en-1-one

SMILES COc1ccc(cc1)C(=O)\C=C\c1ccccc1

InChI Key InChIKey=KJHHAPASNNVTSN-KPKJPENVSA-N

Data  2 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50141532   

TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50141532((E)-1-(4-Methoxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataKi:  22nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI cells assessed as inhibition of H2O2 production using kynuramine as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50141532((E)-1-(4-Methoxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataKi:  1.30E+4nMAssay Description:Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI cells assessed as inhibition of H2O2 production using kynuramine as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50141532((E)-1-(4-Methoxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50:  471nMAssay Description:Inhibition of recombinant human MAOB using benzylamine as substrate after 30 mins by Amplex red based spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50141532((E)-1-(4-Methoxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human MAOA using p-tyramine as substrate after 30 mins by Amplex red based spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThiosulfate sulfurtransferase(Homo sapiens)
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50141532((E)-1-(4-Methoxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of native rhodanese (unknown origin) assessed as reduction in rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChaperonin GroEL(Escherichia coli)
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50141532((E)-1-(4-Methoxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of ATPase activity of Escherichia coli GroEL expressed in Escherichia coliDH5alpha incubated for 60 mins using ATP by spectrometric analys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCo-chaperonin GroES(Escherichia coli)
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50141532((E)-1-(4-Methoxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target60 kDa heat shock protein, mitochondrial(Homo sapiens)
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50141532((E)-1-(4-Methoxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Atherogenics

Curated by ChEMBL
LigandPNGBDBM50141532((E)-1-(4-Methoxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Shaoyang University

LigandPNGBDBM50141532((E)-1-(4-Methoxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50:  1.42E+5nMpH: 6.8 T: 2°CAssay Description:All compounds were dissolved in DMSO (final DMSO concentration in test solution was 2.0%). Phosphate buffer, pH 6.8, was use to dilute the DMSO stoc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCo-chaperonin GroES(Escherichia coli)
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50141532((E)-1-(4-Methoxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed