BDBM50141581 4-(3-Chloro-4-methoxy-benzylamino)-7-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester::CHEMBL41950

SMILES CCOC(=O)c1cnc2cc(ccc2c1NCc1ccc(OC)c(Cl)c1)C(F)(F)F

InChI Key InChIKey=XXAGNOMNFKSMBE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50141581   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50141581(4-(3-Chloro-4-methoxy-benzylamino)-7-trifluorometh...)
Affinity DataIC50:  160nMAssay Description:Inhibition of phosphodiesterase 5 from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50141581(4-(3-Chloro-4-methoxy-benzylamino)-7-trifluorometh...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibitory activity of compound against phosphodiesterase 3 was testedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50141581(4-(3-Chloro-4-methoxy-benzylamino)-7-trifluorometh...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of phosphodiesterase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B(Bos taurus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50141581(4-(3-Chloro-4-methoxy-benzylamino)-7-trifluorometh...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of phosphodiesterase 1 of bovine heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50141581(4-(3-Chloro-4-methoxy-benzylamino)-7-trifluorometh...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of phosphodiesterase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed