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BDBM50142149 5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-hydrazinomethyl-benzoylamino)-benzamide::CHEMBL176736

SMILES: NNCc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1

InChI Key: InChIKey=BEIQTGVHNZJBMA-UHFFFAOYSA-N

Data: 6 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50142149   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Plasminogen


(Homo sapiens (Human))
BDBM50142149
PNG
(5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-hydrazinom...)
Show SMILES NNCc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1
Show InChI InChI=1S/C20H17Cl2N5O2/c21-14-5-7-17(26-19(28)13-3-1-12(2-4-13)10-25-23)16(9-14)20(29)27-18-8-6-15(22)11-24-18/h1-9,11,25H,10,23H2,(H,26,28)(H,24,27,29)
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n/an/a>1.10E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against plasmin.


Bioorg Med Chem Lett 14: 989-93 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.080
BindingDB Entry DOI: 10.7270/Q2X34WXD
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50142149
PNG
(5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-hydrazinom...)
Show SMILES NNCc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1
Show InChI InChI=1S/C20H17Cl2N5O2/c21-14-5-7-17(26-19(28)13-3-1-12(2-4-13)10-25-23)16(9-14)20(29)27-18-8-6-15(22)11-24-18/h1-9,11,25H,10,23H2,(H,26,28)(H,24,27,29)
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n/an/a 40n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against coagulation factor X.


Bioorg Med Chem Lett 14: 989-93 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.080
BindingDB Entry DOI: 10.7270/Q2X34WXD
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM50142149
PNG
(5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-hydrazinom...)
Show SMILES NNCc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1
Show InChI InChI=1S/C20H17Cl2N5O2/c21-14-5-7-17(26-19(28)13-3-1-12(2-4-13)10-25-23)16(9-14)20(29)27-18-8-6-15(22)11-24-18/h1-9,11,25H,10,23H2,(H,26,28)(H,24,27,29)
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PubMed
n/an/a>1.10E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against thrombin.


Bioorg Med Chem Lett 14: 989-93 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.080
BindingDB Entry DOI: 10.7270/Q2X34WXD
More data for this
Ligand-Target Pair
Trypsin-1


(Homo sapiens (Human))
BDBM50142149
PNG
(5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-hydrazinom...)
Show SMILES NNCc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1
Show InChI InChI=1S/C20H17Cl2N5O2/c21-14-5-7-17(26-19(28)13-3-1-12(2-4-13)10-25-23)16(9-14)20(29)27-18-8-6-15(22)11-24-18/h1-9,11,25H,10,23H2,(H,26,28)(H,24,27,29)
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n/an/a>1.10E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against trypsin.


Bioorg Med Chem Lett 14: 989-93 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.080
BindingDB Entry DOI: 10.7270/Q2X34WXD
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))
BDBM50142149
PNG
(5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-hydrazinom...)
Show SMILES NNCc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1
Show InChI InChI=1S/C20H17Cl2N5O2/c21-14-5-7-17(26-19(28)13-3-1-12(2-4-13)10-25-23)16(9-14)20(29)27-18-8-6-15(22)11-24-18/h1-9,11,25H,10,23H2,(H,26,28)(H,24,27,29)
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n/an/a>1.10E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against tissue type plasminogen activator.


Bioorg Med Chem Lett 14: 989-93 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.080
BindingDB Entry DOI: 10.7270/Q2X34WXD
More data for this
Ligand-Target Pair
Vitamin K-dependent protein C


(Homo sapiens (Human))
BDBM50142149
PNG
(5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-hydrazinom...)
Show SMILES NNCc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1
Show InChI InChI=1S/C20H17Cl2N5O2/c21-14-5-7-17(26-19(28)13-3-1-12(2-4-13)10-25-23)16(9-14)20(29)27-18-8-6-15(22)11-24-18/h1-9,11,25H,10,23H2,(H,26,28)(H,24,27,29)
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n/an/a>1.10E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against activated protein C


Bioorg Med Chem Lett 14: 989-93 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.080
BindingDB Entry DOI: 10.7270/Q2X34WXD
More data for this
Ligand-Target Pair