BDBM50142519 CHEMBL47027::N-[2-(3,4,5-triihydroxy-benzoylamino)-phenyl]-3,4,5-trihydroxy-benzamide

SMILES Oc1cc(cc(O)c1O)C(=O)Nc1ccccc1NC(=O)c1cc(O)c(O)c(O)c1

InChI Key InChIKey=KLMQBRFDQLZSNK-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50142519   

TargetDNA topoisomerase 1(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50142519(CHEMBL47027 | N-[2-(3,4,5-triihydroxy-benzoylamino...)
Affinity DataKi:  400nMAssay Description:Inhibition of relaxation activities of DNA topoisomerase I with respect to pBR322 DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50142519(CHEMBL47027 | N-[2-(3,4,5-triihydroxy-benzoylamino...)
Affinity DataKi:  7.41E+4nMAssay Description:Inhibition of relaxation activities of DNA topoisomerase II with respect to pBR322 DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50142519(CHEMBL47027 | N-[2-(3,4,5-triihydroxy-benzoylamino...)
Affinity DataIC50:  9nMAssay Description:Inhibitory concentration against relaxation activity of DNA topoisomerase II by detecting the conversion of supercoiled pBR322 DNA to its relaxed for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50142519(CHEMBL47027 | N-[2-(3,4,5-triihydroxy-benzoylamino...)
Affinity DataIC50:  900nMAssay Description:Inhibitory concentration against relaxation activity of DNA topoisomerase I by detecting the conversion of supercoiled pBR322 DNA to its relaxed formMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed