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BDBM50144084 2-{4-(5-Chloro-1H-indole-2-sulfonyl)-1-[4-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)-benzoyl]-piperazin-2-yl}-1-morpholin-4-yl-ethanone::CHEMBL445616

SMILES: CN1CCN=C1c1ccc(cc1)C(=O)N1CCN(CC1CC(=O)N1CCOCC1)S(=O)(=O)c1cc2cc(Cl)ccc2[nH]1

InChI Key: InChIKey=DEIZNVJVQBVXIX-UHFFFAOYNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50144084   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor X


(Homo sapiens (Human))
BDBM50144084
PNG
(2-{4-(5-Chloro-1H-indole-2-sulfonyl)-1-[4-(1-methy...)
Show SMILES CN1CCN=C1c1ccc(cc1)C(=O)N1CCN(CC1CC(=O)N1CCOCC1)S(=O)(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1/C29H33ClN6O5S/c1-33-9-8-31-28(33)20-2-4-21(5-3-20)29(38)36-11-10-35(19-24(36)18-27(37)34-12-14-41-15-13-34)42(39,40)26-17-22-16-23(30)6-7-25(22)32-26/h2-7,16-17,24,32H,8-15,18-19H2,1H3
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Similars

Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Coagulation factor X was determined


Bioorg Med Chem Lett 14: 2073-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.049
BindingDB Entry DOI: 10.7270/Q2P84B98
More data for this
Ligand-Target Pair