BDBM50145648 LP-778902::LX1032::LX1606::Telotristat::Xermelo::telotristat etiprate

SMILES Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cc(nc(N)n1)-c1ccc(C[C@H](N)C(O)=O)cc1)C(F)(F)F

InChI Key InChIKey=NCLGDOBQAWBXRA-PGRDOPGGSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50145648   

TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145648(LP-778902 | LX1032 | LX1606 | Telotristat | Xermel...)
Affinity DataIC50:  16nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145648(LP-778902 | LX1032 | LX1606 | Telotristat | Xermel...)
Affinity DataIC50:  16nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandPNGBDBM50145648(LP-778902 | LX1032 | LX1606 | Telotristat | Xermel...)
Affinity DataIC50:  710nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145648(LP-778902 | LX1032 | LX1606 | Telotristat | Xermel...)
Affinity DataIC50:  770nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145648(LP-778902 | LX1032 | LX1606 | Telotristat | Xermel...)
Affinity DataIC50:  64nMAssay Description:Inhibition of Tryptophan hydroxylase 1 (unknown origin) incubated for 4 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed