BDBM50145648 LP-778902::LX1032::LX1606::Telotristat::Xermelo::telotristat etiprate
SMILES Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cc(nc(N)n1)-c1ccc(C[C@H](N)C(O)=O)cc1)C(F)(F)F
InChI Key InChIKey=NCLGDOBQAWBXRA-PGRDOPGGSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50145648
Affinity DataIC50: 16nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 710nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
Affinity DataIC50: 770nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Inhibition of Tryptophan hydroxylase 1 (unknown origin) incubated for 4 hrs by fluorescence based assayMore data for this Ligand-Target Pair