BDBM50147083 1-(4-tert-Butyl-benzyl)-3-isoquinolin-5-yl-urea::CHEMBL323134

SMILES CC(C)(C)c1ccc(CNC(=O)Nc2cccc3cnccc23)cc1

InChI Key InChIKey=RSZMNPKYJGGAMY-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50147083   

TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147083(1-(4-tert-Butyl-benzyl)-3-isoquinolin-5-yl-urea | ...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147083(1-(4-tert-Butyl-benzyl)-3-isoquinolin-5-yl-urea | ...)
Affinity DataKi:  14nMAssay Description:Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced effect by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147083(1-(4-tert-Butyl-benzyl)-3-isoquinolin-5-yl-urea | ...)
Affinity DataIC50:  3nMAssay Description:Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed