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BDBM50148729 CHEMBL3770923::US9518026, Example 66

SMILES: CC(C)(C)n1nc(c(C(N)=O)c1N)-c1cnc2cc(OC(F)(F)F)ccc2c1

InChI Key: InChIKey=YJMHWCFTOAMRPN-UHFFFAOYSA-N

Data: 3 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50148729   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calmodulin-domain protein kinase 1 (CDPK1)


(Toxoplasma gondii)
BDBM50148729
PNG
(CHEMBL3770923 | US9518026, Example 66)
Show SMILES CC(C)(C)n1nc(c(C(N)=O)c1N)-c1cnc2cc(OC(F)(F)F)ccc2c1
Show InChI InChI=1S/C18H18F3N5O2/c1-17(2,3)26-15(22)13(16(23)27)14(25-26)10-6-9-4-5-11(28-18(19,20)21)7-12(9)24-8-10/h4-8H,22H2,1-3H3,(H2,23,27)
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UniChem

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Article
PubMed
n/an/a 39n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of Toxoplasma gondii CDPK1 assessed as ATP consumption using (Biotin-C6-PLARTLSVAGLPGKK) as substrate after 90 mins by luciferase reporter...


ACS Med Chem Lett 6: 1184-1189 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00319
BindingDB Entry DOI: 10.7270/Q2NK3GXD
More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148729
PNG
(CHEMBL3770923 | US9518026, Example 66)
Show SMILES CC(C)(C)n1nc(c(C(N)=O)c1N)-c1cnc2cc(OC(F)(F)F)ccc2c1
Show InChI InChI=1S/C18H18F3N5O2/c1-17(2,3)26-15(22)13(16(23)27)14(25-26)10-6-9-4-5-11(28-18(19,20)21)7-12(9)24-8-10/h4-8H,22H2,1-3H3,(H2,23,27)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3n/an/an/an/an/an/a



University of Washington Through its Center For Commercialization

US Patent


Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase 1 (CDPK1)


(Toxoplasma gondii)
BDBM50148729
PNG
(CHEMBL3770923 | US9518026, Example 66)
Show SMILES CC(C)(C)n1nc(c(C(N)=O)c1N)-c1cnc2cc(OC(F)(F)F)ccc2c1
Show InChI InChI=1S/C18H18F3N5O2/c1-17(2,3)26-15(22)13(16(23)27)14(25-26)10-6-9-4-5-11(28-18(19,20)21)7-12(9)24-8-10/h4-8H,22H2,1-3H3,(H2,23,27)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5n/an/an/an/an/an/a



University of Washington Through its Center For Commercialization

US Patent


Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair