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BDBM50150754 CHEMBL3775058

SMILES: CCn1cnc2n(Cc3ccc(Cl)cc3)c(=O)[nH]c(=O)c12

InChI Key: InChIKey=ZUHFEYWVQFKDLX-UHFFFAOYSA-N

Data: 7 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50150754   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50150754
PNG
(CHEMBL3775058)
Show SMILES CCn1cnc2n(Cc3ccc(Cl)cc3)c(=O)[nH]c(=O)c12
Show InChI InChI=1S/C14H13ClN4O2/c1-2-18-8-16-12-11(18)13(20)17-14(21)19(12)7-9-3-5-10(15)6-4-9/h3-6,8H,2,7H2,1H3,(H,17,20,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

PDB
Article
PubMed
n/an/a 2.60E+3n/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human BRD4 bromodomain1 using H4KAc 5/8/12/16 peptide as substrate incubated overnight by HTRF assay


J Med Chem 59: 1634-41 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01708
BindingDB Entry DOI: 10.7270/Q21N830R
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain testis-specific protein


(Homo sapiens (Human))
BDBM50150754
PNG
(CHEMBL3775058)
Show SMILES CCn1cnc2n(Cc3ccc(Cl)cc3)c(=O)[nH]c(=O)c12
Show InChI InChI=1S/C14H13ClN4O2/c1-2-18-8-16-12-11(18)13(20)17-14(21)19(12)7-9-3-5-10(15)6-4-9/h3-6,8H,2,7H2,1H3,(H,17,20,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 2.30E+3n/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human BRDT bromodomain1 using H4KAc 5/8/12/16 peptide as substrate incubated overnight by HTRF assay


J Med Chem 59: 1634-41 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01708
BindingDB Entry DOI: 10.7270/Q21N830R
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM50150754
PNG
(CHEMBL3775058)
Show SMILES CCn1cnc2n(Cc3ccc(Cl)cc3)c(=O)[nH]c(=O)c12
Show InChI InChI=1S/C14H13ClN4O2/c1-2-18-8-16-12-11(18)13(20)17-14(21)19(12)7-9-3-5-10(15)6-4-9/h3-6,8H,2,7H2,1H3,(H,17,20,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 4.70E+3n/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human BRD2 bromodomain1 using H4KAc 5/8/12/16 peptide as substrate incubated overnight by HTRF assay


J Med Chem 59: 1634-41 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01708
BindingDB Entry DOI: 10.7270/Q21N830R
More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM50150754
PNG
(CHEMBL3775058)
Show SMILES CCn1cnc2n(Cc3ccc(Cl)cc3)c(=O)[nH]c(=O)c12
Show InChI InChI=1S/C14H13ClN4O2/c1-2-18-8-16-12-11(18)13(20)17-14(21)19(12)7-9-3-5-10(15)6-4-9/h3-6,8H,2,7H2,1H3,(H,17,20,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 1.80E+3n/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibition of human BRD3 bromodomain2 using H4KAc 5/8/12/16 peptide as substrate incubated overnight by HTRF assay


J Med Chem 59: 1634-41 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01708
BindingDB Entry DOI: 10.7270/Q21N830R
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50150754
PNG
(CHEMBL3775058)
Show SMILES CCn1cnc2n(Cc3ccc(Cl)cc3)c(=O)[nH]c(=O)c12
Show InChI InChI=1S/C14H13ClN4O2/c1-2-18-8-16-12-11(18)13(20)17-14(21)19(12)7-9-3-5-10(15)6-4-9/h3-6,8H,2,7H2,1H3,(H,17,20,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

PDB
Article
PubMed
n/an/a 1.90E+3n/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human BRD4 bromodomain2 using H4KAc 5/8/12/16 peptide as substrate incubated overnight by HTRF assay


J Med Chem 59: 1634-41 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01708
BindingDB Entry DOI: 10.7270/Q21N830R
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50150754
PNG
(CHEMBL3775058)
Show SMILES CCn1cnc2n(Cc3ccc(Cl)cc3)c(=O)[nH]c(=O)c12
Show InChI InChI=1S/C14H13ClN4O2/c1-2-18-8-16-12-11(18)13(20)17-14(21)19(12)7-9-3-5-10(15)6-4-9/h3-6,8H,2,7H2,1H3,(H,17,20,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

PDB
Article
PubMed
n/an/an/a 1.80E+3n/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Binding affinity to his-tagged human BRD4 bromodomain1 by isothermal titration calorimetric analysis


J Med Chem 59: 1634-41 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01708
BindingDB Entry DOI: 10.7270/Q21N830R
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM50150754
PNG
(CHEMBL3775058)
Show SMILES CCn1cnc2n(Cc3ccc(Cl)cc3)c(=O)[nH]c(=O)c12
Show InChI InChI=1S/C14H13ClN4O2/c1-2-18-8-16-12-11(18)13(20)17-14(21)19(12)7-9-3-5-10(15)6-4-9/h3-6,8H,2,7H2,1H3,(H,17,20,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 1.60E+3n/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human BRD2 bromodomain2 using H4KAc 5/8/12/16 peptide as substrate incubated overnight by HTRF assay


J Med Chem 59: 1634-41 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01708
BindingDB Entry DOI: 10.7270/Q21N830R
More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM50150754
PNG
(CHEMBL3775058)
Show SMILES CCn1cnc2n(Cc3ccc(Cl)cc3)c(=O)[nH]c(=O)c12
Show InChI InChI=1S/C14H13ClN4O2/c1-2-18-8-16-12-11(18)13(20)17-14(21)19(12)7-9-3-5-10(15)6-4-9/h3-6,8H,2,7H2,1H3,(H,17,20,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 1.80E+3n/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human BRD3 bromodomain1 using H4KAc 5/8/12/16 peptide as substrate incubated overnight by HTRF assay


J Med Chem 59: 1634-41 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01708
BindingDB Entry DOI: 10.7270/Q21N830R
More data for this
Ligand-Target Pair