BDBM50151637 8''-chloro-5''-(3-dimethylaminopropoxy)spiro[cyclohexane-1,4''-(1'',2'',3'',4''-tetrahydroquinazoline)]-2''-one::CHEMBL185108
SMILES CN(C)CCCOc1ccc(Cl)c2NC(=O)NC3(CCCCC3)c12
InChI Key InChIKey=RYMSZFRCYIQMRX-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50151637
Affinity DataIC50: 9.80E+4nMAssay Description:Inhibition of human PDE5 partially purified from MCF-7 cellsMore data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: >1.01E+5nMAssay Description:Inhibition of human PDE1 partially purified from THP-1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.01E+5nMAssay Description:Inhibition of human PDE3A3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.37E+4nMAssay Description:Inhibition of human PDE4D3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair