BDBM50151639 5''-(2-aminoethoxy)-8''-chlorospiro[cyclohexane-1,4''-(1'',2'',3'',4''-tetrahydroquinazoline)]-2''-one::CHEMBL185275

SMILES NCCOc1ccc(Cl)c2NC(=O)NC3(CCCCC3)c12

InChI Key InChIKey=FOZAKJPJCVQJGR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50151639   

LigandPNGBDBM50151639(5''-(2-aminoethoxy)-8''-chlorospiro[cyclohexane-1,...)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of human PDE1 partially purified from THP-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151639(5''-(2-aminoethoxy)-8''-chlorospiro[cyclohexane-1,...)
Affinity DataIC50:  7.32E+4nMAssay Description:Inhibition of human PDE5 partially purified from MCF-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151639(5''-(2-aminoethoxy)-8''-chlorospiro[cyclohexane-1,...)
Affinity DataIC50:  1.04E+3nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151639(5''-(2-aminoethoxy)-8''-chlorospiro[cyclohexane-1,...)
Affinity DataIC50: >1.01E+5nMAssay Description:Inhibition of human PDE3A3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151639(5''-(2-aminoethoxy)-8''-chlorospiro[cyclohexane-1,...)
Affinity DataIC50:  1.05E+4nMAssay Description:Inhibition of human PDE4D3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed