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BDBM50153305 1-[4-Ethyl-2-hydroxy-6-(3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-3-naphthalen-2-yl-propan-1-one::CHEMBL184364

SMILES: CCc1cc(O)c(C(=O)CCc2ccc3ccccc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1

InChI Key: InChIKey=JVBJTLHQLXTUOY-UIKHAHSZSA-N

Data: 2 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50153305   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50153305
PNG
(1-[4-Ethyl-2-hydroxy-6-(3,4,5-trihydroxy-6-hydroxy...)
Show SMILES CCc1cc(O)c(C(=O)CCc2ccc3ccccc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C27H30O8/c1-2-15-12-20(30)23(19(29)10-8-16-7-9-17-5-3-4-6-18(17)11-16)21(13-15)34-27-26(33)25(32)24(31)22(14-28)35-27/h3-7,9,11-13,22,24-28,30-33H,2,8,10,14H2,1H3/t22-,24-,25+,26-,27-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
10n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Bioorg Med Chem Lett 14: 5121-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.082
BindingDB Entry DOI: 10.7270/Q2VD6XX2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50153305
PNG
(1-[4-Ethyl-2-hydroxy-6-(3,4,5-trihydroxy-6-hydroxy...)
Show SMILES CCc1cc(O)c(C(=O)CCc2ccc3ccccc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C27H30O8/c1-2-15-12-20(30)23(19(29)10-8-16-7-9-17-5-3-4-6-18(17)11-16)21(13-15)34-27-26(33)25(32)24(31)22(14-28)35-27/h3-7,9,11-13,22,24-28,30-33H,2,8,10,14H2,1H3/t22-,24-,25+,26-,27-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
6.50E+3n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1


Bioorg Med Chem Lett 14: 5121-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.082
BindingDB Entry DOI: 10.7270/Q2VD6XX2
More data for this
Ligand-Target Pair