BDBM50154904 CHEMBL3775961::US10273244, Example 231::US10584135, Example 231

SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CCCN(C3C2)c2ccc(cc2)C(F)(F)F)n1C

InChI Key InChIKey=LSEKXOSZIOVUOY-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50154904   

TargetD(3) dopamine receptor(Homo sapiens (Human))
Indivior

US Patent
LigandPNGBDBM50154904(CHEMBL3775961 | US10273244, Example 231 | US105841...)
Affinity DataKi:  11.5nMAssay Description:[3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(3) dopamine receptor(Homo sapiens (Human))
Indivior

US Patent
LigandPNGBDBM50154904(CHEMBL3775961 | US10273244, Example 231 | US105841...)
Affinity DataKi:  11.5nMAssay Description:3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(3) dopamine receptor(Homo sapiens (Human))
Indivior

US Patent
LigandPNGBDBM50154904(CHEMBL3775961 | US10273244, Example 231 | US105841...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Indivior

US Patent
LigandPNGBDBM50154904(CHEMBL3775961 | US10273244, Example 231 | US105841...)
Affinity DataKi:  331nMAssay Description:CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Indivior

US Patent
LigandPNGBDBM50154904(CHEMBL3775961 | US10273244, Example 231 | US105841...)
Affinity DataKi:  331nMAssay Description:Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...More data for this Ligand-Target Pair
In DepthDetails US Patent